2ecw

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{{Seed}}
 
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[[Image:2ecw.png|left|200px]]
 
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==Solution structure of the Zinc finger, C3HC4 type (RING finger) domain Tripartite motif protein 30==
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The line below this paragraph, containing "STRUCTURE_2ecw", creates the "Structure Box" on the page.
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<StructureSection load='2ecw' size='340' side='right'caption='[[2ecw]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ecw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ECW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_2ecw| PDB=2ecw | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ecw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ecw OCA], [https://pdbe.org/2ecw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ecw RCSB], [https://www.ebi.ac.uk/pdbsum/2ecw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ecw ProSAT], [https://www.topsan.org/Proteins/RSGI/2ecw TOPSAN]</span></td></tr>
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</table>
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===Solution structure of the Zinc finger, C3HC4 type (RING finger) domain Tripartite motif protein 30===
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== Function ==
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[https://www.uniprot.org/uniprot/TR30A_MOUSE TR30A_MOUSE] Trans-acting factor that regulates gene expression of interleukin 2 receptor alpha chain. May affect IL2R-alpha expression through cis-acting negative regulatory elements or through competition with proteins that bind to enhancer or activator sequences. Negatively regulates Toll-like receptor (TLR)-mediated activation of NFKB by promoting degradation of TAB2 and TAB3 and preventing TRAF6 autoubiquitination. Negatively regulates production of reactive oxygen species (ROS) which inhibits activation of the NLRP3 inflammasome complex. This, in turn, regulates activation of CASP1 and subsequent cleavage of IL1B and IL18. No activity detected against a range of retroviruses including a number of lentiviruses, gammaretroviruses and betaretroviruses.<ref>PMID:18345001</ref> <ref>PMID:19147168</ref> <ref>PMID:21048113</ref>
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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2ECW is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECW OCA].
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ec/2ecw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ecw ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Abe, H.]]
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[[Category: Abe H]]
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[[Category: Kigawa, T.]]
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[[Category: Kigawa T]]
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[[Category: Miyamoto, K.]]
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[[Category: Miyamoto K]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Tochio N]]
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[[Category: Tochio, N.]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S.]]
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[[Category: Yoneyama M]]
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[[Category: Yoneyama, M.]]
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[[Category: Apoptosis]]
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[[Category: Metal binding protein]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 13 10:04:11 2009''
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Current revision

Solution structure of the Zinc finger, C3HC4 type (RING finger) domain Tripartite motif protein 30

PDB ID 2ecw

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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