3h71

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{{Seed}}
 
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[[Image:3h71.jpg|left|200px]]
 
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==Crystal structure of Streptococcus pneumoniae D39 neuraminidase A precursor (NanA)==
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The line below this paragraph, containing "STRUCTURE_3h71", creates the "Structure Box" on the page.
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<StructureSection load='3h71' size='340' side='right'caption='[[3h71]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3h71]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_R6 Streptococcus pneumoniae R6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H71 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H71 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_3h71| PDB=3h71 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h71 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h71 OCA], [https://pdbe.org/3h71 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h71 RCSB], [https://www.ebi.ac.uk/pdbsum/3h71 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h71 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NANA_STRR6 NANA_STRR6]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h7/3h71_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3h71 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Currently there is pressing need to develop novel therapeutic agents for the treatment of infections by the human respiratory pathogens Pseudomonas aeruginosa and Streptococcus pneumoniae. The neuraminidases of these pathogens are important for host colonization in animal models of infection and are attractive targets for drug discovery. To aid in the development of inhibitors against these neuraminidases, we have determined the crystal structures of the P. aeruginosa enzyme NanPs and S. pneumoniae enzyme NanA at 1.6 and 1.7A resolution, respectively. In situ proteolysis with trypsin was essential for the crystallization of our recombinant NanA. The active site regions of the two enzymes are strikingly different. NanA contains a deep pocket that is similar to that in canonical neuraminidases, while the NanPs active site is much more open. The comparative studies suggest that NanPs may not be a classical neuraminidase, and may have distinct natural substrates and physiological functions. This work represents an important step in the development of drugs to prevent respiratory tract colonization by these two pathogens.
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===Crystal structure of Streptococcus pneumoniae D39 neuraminidase A precursor (NanA)===
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Crystal structures of respiratory pathogen neuraminidases.,Hsiao YS, Parker D, Ratner AJ, Prince A, Tong L Biochem Biophys Res Commun. 2009 Mar 13;380(3):467-71. Epub 2009 Jan 23. PMID:19284989<ref>PMID:19284989</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3h71" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19284989}}, adds the Publication Abstract to the page
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*[[Neuraminidase 3D structures|Neuraminidase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19284989 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19284989}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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3H71 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H71 OCA].
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[[Category: Streptococcus pneumoniae R6]]
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[[Category: Hsiao Y-S]]
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==Reference==
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[[Category: Tong L]]
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<ref group="xtra">PMID:19284989</ref><references group="xtra"/>
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[[Category: Exo-alpha-sialidase]]
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[[Category: Streptococcus pneumoniae]]
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[[Category: Hsiao, Y S.]]
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[[Category: Tong, L.]]
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[[Category: Cell wall]]
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[[Category: Glycosidase]]
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[[Category: Hydrolase]]
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[[Category: Peptidoglycan-anchor]]
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[[Category: Secreted]]
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[[Category: Six-bladed beta-propeller]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 13 10:05:29 2009''
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Current revision

Crystal structure of Streptococcus pneumoniae D39 neuraminidase A precursor (NanA)

PDB ID 3h71

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