This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1icl
From Proteopedia
(Difference between revisions)
(New page: 200px<br /><applet load="1icl" size="450" color="white" frame="true" align="right" spinBox="true" caption="1icl" /> '''SOLUTION STRUCTURE OF DESIGNED BETA-SHEET MI...) |
|||
| (14 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:1icl.jpg|left|200px]]<br /><applet load="1icl" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1icl" /> | ||
| - | '''SOLUTION STRUCTURE OF DESIGNED BETA-SHEET MINI-PROTEIN TH1OX'''<br /> | ||
| - | == | + | ==SOLUTION STRUCTURE OF DESIGNED BETA-SHEET MINI-PROTEIN TH1OX== |
| - | Here we report the creation of a predominantly beta-structured | + | <StructureSection load='1icl' size='340' side='right'caption='[[1icl]]' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1icl]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ICL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ICL FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DPR:D-PROLINE'>DPR</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1icl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1icl OCA], [https://pdbe.org/1icl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1icl RCSB], [https://www.ebi.ac.uk/pdbsum/1icl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1icl ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Here we report the creation of a predominantly beta-structured mini-protein motif. The design target is based on the naturally occurring toxin hand (TH) motifs that are composed of four disulfide bonds and three loops that form a 'hand'. Analysis and subsequent modification of several generations of mini-proteins produced the final 29-residue mini-protein. The structured motif of this new mini-protein provides insight into the compensatory changes that result in the formation of a tightly packed hydrophobic core in a small, globular beta-structure motif. Additionally, this mini-motif represents a new, distinct surface topology for protein design and a valuable, yet compact, model system for the study of beta-sheet structure in water. | ||
| - | + | Design of a discretely folded mini-protein motif with predominantly beta-structure.,Ottesen JJ, Imperiali B Nat Struct Biol. 2001 Jun;8(6):535-9. PMID:11373623<ref>PMID:11373623</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | [[Category: | + | <div class="pdbe-citations 1icl" style="background-color:#fffaf0;"></div> |
| - | [[Category: Imperiali | + | == References == |
| - | [[Category: Ottesen | + | <references/> |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Large Structures]] | |
| + | [[Category: Imperiali B]] | ||
| + | [[Category: Ottesen JJ]] | ||
Current revision
SOLUTION STRUCTURE OF DESIGNED BETA-SHEET MINI-PROTEIN TH1OX
| |||||||||||
