1wj1

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{{Seed}}
 
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[[Image:1wj1.png|left|200px]]
 
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==Solution structure of phosphotyrosine interaction domain of mouse Numb protein==
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The line below this paragraph, containing "STRUCTURE_1wj1", creates the "Structure Box" on the page.
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<StructureSection load='1wj1' size='340' side='right'caption='[[1wj1]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1wj1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WJ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WJ1 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wj1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wj1 OCA], [https://pdbe.org/1wj1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wj1 RCSB], [https://www.ebi.ac.uk/pdbsum/1wj1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wj1 ProSAT], [https://www.topsan.org/Proteins/RSGI/1wj1 TOPSAN]</span></td></tr>
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{{STRUCTURE_1wj1| PDB=1wj1 | SCENE= }}
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</table>
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== Function ==
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===Solution structure of phosphotyrosine interaction domain of mouse Numb protein===
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[https://www.uniprot.org/uniprot/NUMB_MOUSE NUMB_MOUSE] Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.<ref>PMID:10841580</ref> <ref>PMID:12410312</ref> <ref>PMID:15273690</ref> <ref>PMID:17174898</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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1WJ1 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WJ1 OCA].
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wj/1wj1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wj1 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Inoue, M.]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T.]]
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[[Category: Kigawa T]]
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[[Category: Koshiba, S.]]
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[[Category: Koshiba S]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Sato M]]
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[[Category: Sato, M.]]
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[[Category: Tochio N]]
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[[Category: Tochio, N.]]
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[[Category: Tomizawa T]]
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[[Category: Tomizawa, T.]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S.]]
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[[Category: Numb protein]]
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[[Category: Pid domain]]
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[[Category: Ptb]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Signaling protein]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 13 10:29:31 2009''
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Current revision

Solution structure of phosphotyrosine interaction domain of mouse Numb protein

PDB ID 1wj1

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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