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3gb5

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{{Seed}}
 
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[[Image:3gb5.jpg|left|200px]]
 
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==Crystal structure of Mus musculus iodotyrosine deiodinase (IYD) bound to FMN==
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The line below this paragraph, containing "STRUCTURE_3gb5", creates the "Structure Box" on the page.
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<StructureSection load='3gb5' size='340' side='right'caption='[[3gb5]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3gb5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GB5 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_3gb5| PDB=3gb5 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gb5 OCA], [https://pdbe.org/3gb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gb5 RCSB], [https://www.ebi.ac.uk/pdbsum/3gb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gb5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IYD1_MOUSE IYD1_MOUSE] Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gb/3gb5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gb5 ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of Mus musculus iodotyrosine deiodinase (IYD) bound to FMN===
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==See Also==
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*[[Dehalogenase 3D structures|Dehalogenase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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3GB5 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GB5 OCA].
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Adler, J M.]]
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[[Category: Adler JM]]
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[[Category: LaRonde-LeBlanc, N.]]
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[[Category: LaRonde-LeBlanc N]]
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[[Category: McTamney, P M.]]
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[[Category: McTamney PM]]
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[[Category: Rokita, S E.]]
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[[Category: Rokita SE]]
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[[Category: Thomas, S R.]]
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[[Category: Thomas SR]]
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[[Category: Flavoprotein]]
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[[Category: Fmn]]
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[[Category: Iodide salvage]]
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[[Category: Iyd]]
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[[Category: Membrane]]
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[[Category: Nadp]]
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[[Category: Oxidoreductase]]
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[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 13 10:31:38 2009''
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Current revision

Crystal structure of Mus musculus iodotyrosine deiodinase (IYD) bound to FMN

PDB ID 3gb5

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