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3h8q

From Proteopedia

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{{Seed}}
 
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[[Image:3h8q.jpg|left|200px]]
 
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==Crystal structure of glutaredoxin domain of human thioredoxin reductase 3==
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The line below this paragraph, containing "STRUCTURE_3h8q", creates the "Structure Box" on the page.
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<StructureSection load='3h8q' size='340' side='right'caption='[[3h8q]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3h8q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H8Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H8Q FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.21&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3h8q| PDB=3h8q | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h8q OCA], [https://pdbe.org/3h8q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h8q RCSB], [https://www.ebi.ac.uk/pdbsum/3h8q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h8q ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRXR3_HUMAN TRXR3_HUMAN] Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity).[UniProtKB:Q99MD6]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h8/3h8q_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3h8q ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of glutaredoxin domain of human thioredoxin reductase 3===
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==See Also==
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*[[Thioredoxin reductase 3D structures|Thioredoxin reductase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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3H8Q is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H8Q OCA].
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Thioredoxin-disulfide reductase]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C.]]
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[[Category: Bountra C]]
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[[Category: Chaikuad, A.]]
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[[Category: Chaikuad A]]
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[[Category: Delft, F von.]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A M.]]
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[[Category: Johansson C]]
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[[Category: Johansson, C.]]
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[[Category: Oppermann U]]
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[[Category: Oppermann, U.]]
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[[Category: Pilka E]]
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[[Category: Pilka, E.]]
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[[Category: Roos AK]]
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[[Category: Roos, A K.]]
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[[Category: Ugochukwu E]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Weigelt J]]
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[[Category: Ugochukwu, E.]]
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[[Category: Yue W]]
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[[Category: Weigelt, J.]]
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[[Category: Von Delft F]]
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[[Category: Yue, W.]]
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[[Category: Cytoplasm]]
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[[Category: Developmental protein]]
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[[Category: Differentiation]]
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[[Category: Disulfide bond]]
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[[Category: Electron transport]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Fad]]
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[[Category: Flavoprotein]]
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[[Category: Microsome]]
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[[Category: Nadp]]
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[[Category: Nucleus]]
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[[Category: Oxidoreductase]]
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[[Category: Phosphoprotein]]
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[[Category: Redox-active center]]
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[[Category: Selenium]]
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[[Category: Selenocysteine]]
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[[Category: Sgc]]
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[[Category: Spermatogenesis]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: Transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 13 10:37:10 2009''
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Current revision

Crystal structure of glutaredoxin domain of human thioredoxin reductase 3

PDB ID 3h8q

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