3ha7

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[[Image:3ha7.jpg|left|200px]]
 
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==Crystal structure of HMA (MMAA4) from mycobacterium tuberculosis complexed with S-adenosyl-N-decyl-aminoethyl (SADAE)==
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<StructureSection load='3ha7' size='340' side='right'caption='[[3ha7]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ha7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HA7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HA7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B32:5-S-[2-(DECYLAMINO)ETHYL]-5-THIOADENOSINE'>B32</scene></td></tr>
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{{STRUCTURE_3ha7| PDB=3ha7 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ha7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ha7 OCA], [https://pdbe.org/3ha7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ha7 RCSB], [https://www.ebi.ac.uk/pdbsum/3ha7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ha7 ProSAT]</span></td></tr>
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</table>
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===Crystal structure of HMA (MMAA4) from mycobacterium tuberculosis complexed with S-adenosyl-N-decyl-aminoethyl (SADAE)===
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== Function ==
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[https://www.uniprot.org/uniprot/MMAA4_MYCTU MMAA4_MYCTU] Involved in the biosynthesis of hydroxymycolate, a common precursor of oxygenated mycolic acids (methoxy-mycolate and keto-mycolate). Probably transfers a methyl group from the S-adenosylmethionine (SAM) cofactor and, subsequently or simultaneously, a water molecule onto the double bound of ethylene substrates, leading to the formation of the hydroxylated product at the distal position. Involved in the activation of the antitubercular drug thiacetazone (TAC).<ref>PMID:10844652</ref> <ref>PMID:12473649</ref>
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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3HA7 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HA7 OCA].
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Check<jmol>
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[[Category: Mycobacterium tuberculosis]]
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<jmolCheckbox>
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[[Category: Boissier, F.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ha/3ha7_consurf.spt"</scriptWhenChecked>
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[[Category: Julien, S.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Mourey, L.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Vaubourgeix, J.]]
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</jmolCheckbox>
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[[Category: Methyltransferase]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ha7 ConSurf].
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[[Category: S-adenosylmethionine-dependent methyltransferase fold]]
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<div style="clear:both"></div>
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[[Category: Transferase]]
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== References ==
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<references/>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 13 10:38:28 2009''
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Boissier F]]
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[[Category: Julien S]]
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[[Category: Mourey L]]
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[[Category: Vaubourgeix J]]

Current revision

Crystal structure of HMA (MMAA4) from mycobacterium tuberculosis complexed with S-adenosyl-N-decyl-aminoethyl (SADAE)

PDB ID 3ha7

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