2eel

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{{Seed}}
 
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[[Image:2eel.png|left|200px]]
 
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==Solution structure of the CIDE-N domain of human cell death activator CIDE-A==
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The line below this paragraph, containing "STRUCTURE_2eel", creates the "Structure Box" on the page.
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<StructureSection load='2eel' size='340' side='right'caption='[[2eel]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2eel]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EEL FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eel OCA], [https://pdbe.org/2eel PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eel RCSB], [https://www.ebi.ac.uk/pdbsum/2eel PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eel ProSAT], [https://www.topsan.org/Proteins/RSGI/2eel TOPSAN]</span></td></tr>
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{{STRUCTURE_2eel| PDB=2eel | SCENE= }}
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</table>
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== Disease ==
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===Solution structure of the CIDE-N domain of human cell death activator CIDE-A===
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[https://www.uniprot.org/uniprot/CIDEA_HUMAN CIDEA_HUMAN] Note=In omental and subcutaneous adipose tissue of obese patients matched for BMI, expression levels correlate with insulin sensitivity. Expression is increased 5-6 fold in the group of patients with high insulin sensitivity, compared to the insulin-resistant group. This observation is consistent with the idea that triglyceride storage in adipocytes plays an important role in sequestering triglycerides and fatty acids away from the circulation and peripheral tissues, thus enhancing insulin sensitivity in liver and muscle.<ref>PMID:18509062</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/CIDEA_HUMAN CIDEA_HUMAN] Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (By similarity). Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear.<ref>PMID:19843876</ref>
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==About this Structure==
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== Evolutionary Conservation ==
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2EEL is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EEL OCA].
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ee/2eel_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2eel ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hayashi, F.]]
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[[Category: Large Structures]]
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[[Category: Nagashima, T.]]
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[[Category: Hayashi F]]
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[[Category: Qin, X R.]]
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[[Category: Nagashima T]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Qin XR]]
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[[Category: Yokoyama, S.]]
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[[Category: Yokoyama S]]
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[[Category: Apoptosis]]
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[[Category: Cell death activator cide-a]]
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[[Category: Cell death-inducing dffa-like effector some]]
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[[Category: Cide-n domain]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 13 11:22:09 2009''
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Current revision

Solution structure of the CIDE-N domain of human cell death activator CIDE-A

PDB ID 2eel

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