2e5r

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{{Seed}}
 
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[[Image:2e5r.png|left|200px]]
 
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==Solution structure of the ZZ domain of Dystrobrevin alpha (Dystrobrevin-alpha)==
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The line below this paragraph, containing "STRUCTURE_2e5r", creates the "Structure Box" on the page.
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<StructureSection load='2e5r' size='340' side='right'caption='[[2e5r]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2e5r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E5R FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_2e5r| PDB=2e5r | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5r OCA], [https://pdbe.org/2e5r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e5r RCSB], [https://www.ebi.ac.uk/pdbsum/2e5r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e5r ProSAT], [https://www.topsan.org/Proteins/RSGI/2e5r TOPSAN]</span></td></tr>
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</table>
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===Solution structure of the ZZ domain of Dystrobrevin alpha (Dystrobrevin-alpha)===
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== Disease ==
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[https://www.uniprot.org/uniprot/DTNA_HUMAN DTNA_HUMAN] Defects in DTNA are the cause of left ventricular non-compaction type 1 (LVNC1) [MIM:[https://omim.org/entry/604169 604169]. Left ventricular non-compaction is due to an arrest of myocardial morphogenesis. The disorder is characterized by a hypertrophic left ventricle with deep trabeculations and with poor systolic function, with or without associated left ventricular dilation. In some cases, it is associated with other congenital heart anomalies such as ventricular septal defects, pulmonic stenosis and atrial septal defects. The right ventricle may also be affected.<ref>PMID:11238270</ref>
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== Function ==
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==Disease==
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[https://www.uniprot.org/uniprot/DTNA_HUMAN DTNA_HUMAN] May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.
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Known disease associated with this structure: Left ventricular noncompaction with congenital heart defects OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601239 601239]], Left ventricular noncompaction, familial isolated, 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601239 601239]]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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2E5R is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5R OCA].
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e5/2e5r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e5r ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Dang, W.]]
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[[Category: Large Structures]]
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[[Category: Inoue, M.]]
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[[Category: Dang W]]
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[[Category: Kigawa, T.]]
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[[Category: Inoue M]]
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[[Category: Muto, Y.]]
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[[Category: Kigawa T]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Muto Y]]
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[[Category: Shirouzu, M.]]
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[[Category: Shirouzu M]]
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[[Category: Terada, T.]]
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[[Category: Terada T]]
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[[Category: Yokoyama, S.]]
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[[Category: Yokoyama S]]
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[[Category: Dna binding protein]]
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[[Category: Dystrobrevin alpha]]
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[[Category: Dystrobrevin-alpha]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nmr]]
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[[Category: Nppsfa]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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[[Category: Zz domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 13 11:28:28 2009''
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Current revision

Solution structure of the ZZ domain of Dystrobrevin alpha (Dystrobrevin-alpha)

PDB ID 2e5r

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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