153d

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(New page: 200px<br /><applet load="153d" size="450" color="white" frame="true" align="right" spinBox="true" caption="153d, resolution 2.900&Aring;" /> '''CRYSTAL STRUCTURE O...)
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[[Image:153d.gif|left|200px]]<br /><applet load="153d" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="153d, resolution 2.900&Aring;" />
 
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'''CRYSTAL STRUCTURE OF A MISPAIRED DODECAMER, D(CGAGAATTC(O6ME)GCG)2, CONTAINING A CARCINOGENIC O6-METHYLGUANINE'''<br />
 
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==Overview==
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==CRYSTAL STRUCTURE OF A MISPAIRED DODECAMER, D(CGAGAATTC(O6ME)GCG)2, CONTAINING A CARCINOGENIC O6-METHYLGUANINE==
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The crystal structure of the synthetic deoxydodecamer, d(CGAGAATTC(O6Me)GCG)2 has been determined and refined to an R-factor of, 16.9% with data up to 2.9-A resolution. This sequence contains two, mismatched base pairs between O6-methylguanine and adenine with the, arrangement A(syn).(O6-Me)G(anti) which differs from the geometry observed, in solution by NMR. The intermolecular arrangement is equivalent to the, other isomorphous deoxydodecamers. However, the weakening of some, significant crystal packing contacts was observed and related to the, effect of stacking between the mispaired adenine and the adjacent guanine, in the sequence. The structure is highly hydrated, with a total of 49, solvent molecules located. The methyl group and the mismatched base-pair, geometry locally disrupt the B-DNA-type solvent network with two solvent, molecules found close to the N1 and N6 of the mispaired adenine.
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<StructureSection load='153d' size='340' side='right'caption='[[153d]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[153d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=153D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=153D FirstGlance]. <br>
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153D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=153D OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6OG:6-O-METHYL+GUANOSINE-5-MONOPHOSPHATE'>6OG</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=153d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=153d OCA], [https://pdbe.org/153d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=153d RCSB], [https://www.ebi.ac.uk/pdbsum/153d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=153d ProSAT]</span></td></tr>
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Crystal structure of a mispaired dodecamer, d(CGAGAATTC(O6Me)GCG)2, containing a carcinogenic O6-methylguanine., Ginell SL, Vojtechovsky J, Gaffney B, Jones R, Berman HM, Biochemistry. 1994 Mar 29;33(12):3487-93. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8142345 8142345]
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</table>
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[[Category: Protein complex]]
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__TOC__
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[[Category: Berman, H.M.]]
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</StructureSection>
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[[Category: Gaffney, B.]]
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[[Category: Large Structures]]
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[[Category: Ginell, S.L.]]
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[[Category: Berman HM]]
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[[Category: Jones, R.]]
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[[Category: Gaffney B]]
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[[Category: Vojtechovsky, J.]]
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[[Category: Ginell SL]]
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[[Category: b-dna]]
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[[Category: Jones R]]
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[[Category: double helix]]
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[[Category: Vojtechovsky J]]
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[[Category: mismatched]]
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[[Category: modified]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 21:58:44 2007''
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Current revision

CRYSTAL STRUCTURE OF A MISPAIRED DODECAMER, D(CGAGAATTC(O6ME)GCG)2, CONTAINING A CARCINOGENIC O6-METHYLGUANINE

PDB ID 153d

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