159d

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(New page: 200px<br /><applet load="159d" size="450" color="white" frame="true" align="right" spinBox="true" caption="159d, resolution 1.800&Aring;" /> '''SIDE BY SIDE BINDIN...)
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[[Image:159d.gif|left|200px]]<br /><applet load="159d" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="159d, resolution 1.800&Aring;" />
 
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'''SIDE BY SIDE BINDING OF TWO DISTAMYCIN A DRUGS IN THE MINOR GROOVE OF AN ALTERNATING B-DNA DUPLEX'''<br />
 
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==Overview==
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==SIDE BY SIDE BINDING OF TWO DISTAMYCIN A DRUGS IN THE MINOR GROOVE OF AN ALTERNATING B-DNA DUPLEX==
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Here we report the 1.8A X-ray structure of a 2:1 drug-DNA complex between, distamycin A and an alternating B-DNA octamer duplex d(ICICICIC)2. The two, distamycin A molecules are bound side by side with dyad symmetry in an, antiparallel orientation in the expanded minor groove. The amides of each, drug molecule are hydrogen bonded to the minor groove base atoms of only, one DNA strand. The complex not only shows binding of two drug molecules, but the DNA duplex also exhibits striking low-high alternations in the, helical twist angles, the sugar puckering and the phosphate conformations, providing the basis for a new model for an alternating B-DNA with a, dinucleotide repeat.
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<StructureSection load='159d' size='340' side='right'caption='[[159d]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[159d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=159D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=159D FirstGlance]. <br>
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159D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with DMY and MG as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=159D OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMY:DISTAMYCIN+A'>DMY</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=159d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=159d OCA], [https://pdbe.org/159d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=159d RCSB], [https://www.ebi.ac.uk/pdbsum/159d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=159d ProSAT]</span></td></tr>
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Binding of two distamycin A molecules in the minor groove of an alternating B-DNA duplex., Chen X, Ramakrishnan B, Rao ST, Sundaralingam M, Nat Struct Biol. 1994 Mar;1(3):169-75. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7656035 7656035]
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</table>
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[[Category: Protein complex]]
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__TOC__
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[[Category: Chen, X.]]
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</StructureSection>
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[[Category: Ramakrishnan, B.]]
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[[Category: Large Structures]]
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[[Category: Rao, S.T.]]
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[[Category: Chen X]]
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[[Category: Sundaralingam, M.]]
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[[Category: Ramakrishnan B]]
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[[Category: DMY]]
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[[Category: Rao ST]]
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[[Category: MG]]
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[[Category: Sundaralingam M]]
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[[Category: b-dna]]
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[[Category: complexed with drug]]
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[[Category: double helix]]
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[[Category: modified]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 22:00:39 2007''
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Current revision

SIDE BY SIDE BINDING OF TWO DISTAMYCIN A DRUGS IN THE MINOR GROOVE OF AN ALTERNATING B-DNA DUPLEX

PDB ID 159d

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