3h6n

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{{Seed}}
 
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[[Image:3h6n.jpg|left|200px]]
 
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==Crystal Structure of the ubiquitin-like domain of plexin D1==
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The line below this paragraph, containing "STRUCTURE_3h6n", creates the "Structure Box" on the page.
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<StructureSection load='3h6n' size='340' side='right'caption='[[3h6n]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3h6n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H6N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H6N FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.004&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ARS:ARSENIC'>ARS</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_3h6n| PDB=3h6n | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h6n OCA], [https://pdbe.org/3h6n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h6n RCSB], [https://www.ebi.ac.uk/pdbsum/3h6n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h6n ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/PLXD1_HUMAN PLXD1_HUMAN] Truncus arteriosus.
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== Function ==
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[https://www.uniprot.org/uniprot/PLXD1_HUMAN PLXD1_HUMAN] Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature (By similarity). Mediates anti-angiogenic signaling in response to SEMA3E.<ref>PMID:20385769</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h6/3h6n_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3h6n ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of the ubiquitin-like domain of plexin D1===
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==See Also==
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*[[Plexin 3D structures|Plexin 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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3H6N is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H6N OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Bochkarev, A.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C.]]
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[[Category: Bochkarev A]]
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[[Category: Buck, M.]]
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[[Category: Bountra C]]
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[[Category: Edwards, A M.]]
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[[Category: Buck M]]
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[[Category: MacKenzie, F.]]
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[[Category: Edwards AM]]
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[[Category: Nedyalkova, L.]]
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[[Category: MacKenzie F]]
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[[Category: Park, H.]]
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[[Category: Nedyalkova L]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Park H]]
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[[Category: Tempel, W.]]
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[[Category: Tempel W]]
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[[Category: Tong, Y.]]
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[[Category: Tong Y]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Alternative splicing]]
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[[Category: Cell membrane]]
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[[Category: Glycoprotein]]
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[[Category: Membrane]]
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[[Category: Polymorphism]]
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[[Category: Receptor]]
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[[Category: Sgc]]
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[[Category: Signaling protein]]
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[[Category: Structural genomics consortium]]
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[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 20 18:06:02 2009''
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Current revision

Crystal Structure of the ubiquitin-like domain of plexin D1

PDB ID 3h6n

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