2ie4

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{{Seed}}
 
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[[Image:2ie4.png|left|200px]]
 
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==Structure of the Protein Phosphatase 2A Core Enzyme Bound to okadaic acid==
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The line below this paragraph, containing "STRUCTURE_2ie4", creates the "Structure Box" on the page.
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<StructureSection load='2ie4' size='340' side='right'caption='[[2ie4]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ie4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IE4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IE4 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=OKA:OKADAIC+ACID'>OKA</scene></td></tr>
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{{STRUCTURE_2ie4| PDB=2ie4 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ie4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ie4 OCA], [https://pdbe.org/2ie4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ie4 RCSB], [https://www.ebi.ac.uk/pdbsum/2ie4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ie4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/2AAA_HUMAN 2AAA_HUMAN] The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis.<ref>PMID:16580887</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ie/2ie4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ie4 ConSurf].
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<div style="clear:both"></div>
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===Structure of the Protein Phosphatase 2A Core Enzyme Bound to okadaic acid===
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==See Also==
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*[[Protein phosphatase 3D structures|Protein phosphatase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_17055435}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 17055435 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_17055435}}
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==About this Structure==
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2IE4 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IE4 OCA]. Relevant biological numbers for this protein at [http://bionumbers.hms.harvard.edu/search.aspx?log=y&task=searchbytrmorg&trm=%22phosphatase%22&org=%25 B10NUMB3R5]
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==Reference==
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<ref group="xtra">PMID:17055435</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Phosphoprotein phosphatase]]
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[[Category: Large Structures]]
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[[Category: Chao, Y.]]
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[[Category: Chao Y]]
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[[Category: Chen, Y.]]
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[[Category: Chen Y]]
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[[Category: Jeffrey, P D.]]
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[[Category: Jeffrey PD]]
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[[Category: Shi, Y.]]
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[[Category: Shi Y]]
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[[Category: Xing, Y.]]
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[[Category: Xing Y]]
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[[Category: Xu, Y.]]
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[[Category: Xu Y]]
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[[Category: Heat repeat]]
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[[Category: Hydrolase]]
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[[Category: Protein-protein complex]]
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[[Category: Signaling protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon May 25 08:15:00 2009''
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Current revision

Structure of the Protein Phosphatase 2A Core Enzyme Bound to okadaic acid

PDB ID 2ie4

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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