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2o8a

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{{Seed}}
 
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[[Image:2o8a.png|left|200px]]
 
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==rat PP1cgamma complexed with mouse inhibitor-2==
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The line below this paragraph, containing "STRUCTURE_2o8a", creates the "Structure Box" on the page.
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<StructureSection load='2o8a' size='340' side='right'caption='[[2o8a]], [[Resolution|resolution]] 2.61&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2o8a]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O8A FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.61&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o8a OCA], [https://pdbe.org/2o8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o8a RCSB], [https://www.ebi.ac.uk/pdbsum/2o8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o8a ProSAT]</span></td></tr>
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{{STRUCTURE_2o8a| PDB=2o8a | SCENE= }}
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</table>
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== Function ==
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===rat PP1cgamma complexed with mouse inhibitor-2===
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[https://www.uniprot.org/uniprot/PP1G_RAT PP1G_RAT] Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_17636256}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 17636256 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o8/2o8a_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_17636256}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2o8a ConSurf].
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2O8A is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O8A OCA]. Relevant biological numbers for this protein at [http://bionumbers.hms.harvard.edu/search.aspx?log=y&task=searchbytrmorg&trm=%22phosphatase%22&org=%25 B10NUMB3R5]
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:17636256</ref><references group="xtra"/>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Phosphoprotein phosphatase]]
 
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Hurley, T D.]]
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[[Category: Hurley TD]]
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[[Category: Hydrolase/inhibitor complex]]
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[[Category: Inhibitor-2]]
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[[Category: Protein phosphatase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon May 25 08:19:58 2009''
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Current revision

rat PP1cgamma complexed with mouse inhibitor-2

PDB ID 2o8a

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