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2kj3
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 2kj3 is ON HOLD Authors: Van Melckebeke, H., Wasmer, C., Lange, A., AB, E., Loquet, A., Meier, B.H. Description: HIGH-RESOLUTION STRUCTURE OF THE H...) |
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| - | '''Unreleased structure''' | ||
| - | The | + | ==High-resolution structure of the HET-s(218-289) prion in its amyloid form obtained by solid-state NMR== |
| + | <StructureSection load='2kj3' size='340' side='right'caption='[[2kj3]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2kj3]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Podospora_anserina Podospora anserina]. The September 2015 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Amyloids'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2015_9 10.2210/rcsb_pdb/mom_2015_9]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KJ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KJ3 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solid-state NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kj3 OCA], [https://pdbe.org/2kj3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kj3 RCSB], [https://www.ebi.ac.uk/pdbsum/2kj3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kj3 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HETS_PODAS HETS_PODAS] Responsible for heterokaryon incompatibility, a process that ensures that during spontaneous, vegetative cell fusion only compatible cells from the same colony survive (non-self-recognition). Forms a prion for the non-Mendelian trait [het-s]. Interacts with het-S from incompatible cells to trigger a lethal reaction that prevents the formation of viable heterokaryons. It is unknown if the native, soluble protein has a cellular function.<ref>PMID:1886611</ref> <ref>PMID:8224826</ref> <ref>PMID:9275200</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Prion 3D structures|Prion 3D structures]] | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Amyloids]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Podospora anserina]] | ||
| + | [[Category: RCSB PDB Molecule of the Month]] | ||
| + | [[Category: AB E]] | ||
| + | [[Category: Lange A]] | ||
| + | [[Category: Loquet A]] | ||
| + | [[Category: Meier BH]] | ||
| + | [[Category: Van Melckebeke H]] | ||
| + | [[Category: Wasmer C]] | ||
Current revision
High-resolution structure of the HET-s(218-289) prion in its amyloid form obtained by solid-state NMR
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