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3bks

From Proteopedia

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{{Seed}}
 
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[[Image:3bks.png|left|200px]]
 
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==Crystal Structure of Sterol Carrier Protein-2 like-3 (SCP2-L3) from Aedes Aegypti==
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The line below this paragraph, containing "STRUCTURE_3bks", creates the "Structure Box" on the page.
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<StructureSection load='3bks' size='340' side='right'caption='[[3bks]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3bks]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aedes_aegypti Aedes aegypti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BKS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BKS FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
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{{STRUCTURE_3bks| PDB=3bks | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bks OCA], [https://pdbe.org/3bks PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bks RCSB], [https://www.ebi.ac.uk/pdbsum/3bks PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bks ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q16LC3_AEDAE Q16LC3_AEDAE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bk/3bks_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bks ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The sterol carrier protein-2 like 3 gene (AeSCP-2L3), a new member of the SCP-2 protein family, is identified from the yellow fever mosquito, Aedes aegypti. The predicted molecular weight of AeSCP-2L3 is 13.4 kDa with a calculated pI of 4.98. AeSCP-2L3 transcription occurs in the larval feeding stages and the mRNA levels decrease in pupae and adults. The highest levels of AeSCP-2L3 gene expression are found in the body wall, and possibly originated in the fat body. This is the first report of a mosquito SCP-2-like protein with prominent expression in tissue other than the midgut. The X-ray protein crystal structure of AeSCP-2L3 reveals a bound C16 fatty acid whose acyl tail penetrates deeply into a hydrophobic cavity. Interestingly, the ligand-binding cavity is slightly larger than previously described for AeSCP-2 (Dyer et al. J Biol Chem 278:39085-39091, 2003) and AeSCP-2L2 (Dyer et al. J Lipid Res M700460-JLR200, 2007). There are also an additional 10 amino acids in SCP-2L3 that are not present in other characterized mosquito SCP-2s forming an extended loop between beta 3 and beta 4. Otherwise, the protein backbone is exceedingly similar to other SCP-2 and SCP-2-like proteins. In contrast to this observed high structural homology of members in the mosquito SCP2 family, the amino acid sequence identity between the members is less than 30%. The results from structural analysis imply that there have been evolutionary constraints that favor the SCP-2 C(alpha) backbone fold while the specificity of ligand binding can be altered.
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===Crystal Structure of Sterol Carrier Protein-2 like-3 (SCP2-L3) from Aedes Aegypti===
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Characterization of the yellow fever mosquito sterol carrier protein-2 like 3 gene and ligand-bound protein structure.,Dyer DH, Vyazunova I, Lorch JM, Forest KT, Lan Q Mol Cell Biochem. 2009 Jun;326(1-2):67-77. Epub 2009 Jan 7. PMID:19130179<ref>PMID:19130179</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19130179}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3bks" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19130179 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19130179}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3BKS is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Aedes_aegypti Aedes aegypti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BKS OCA].
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==Reference==
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<ref group="xtra">PMID:19130179</ref><references group="xtra"/>
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[[Category: Aedes aegypti]]
[[Category: Aedes aegypti]]
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[[Category: Dyer, D H.]]
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[[Category: Large Structures]]
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[[Category: Forest, K T.]]
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[[Category: Dyer DH]]
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[[Category: Lan, Q.]]
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[[Category: Forest KT]]
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[[Category: Cholesterol]]
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[[Category: Lan Q]]
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[[Category: Fatty acid]]
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[[Category: Lipid binding protein]]
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[[Category: Mosquito]]
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[[Category: Palmitic acid]]
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[[Category: Sterol carrier]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 27 14:34:53 2009''
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Current revision

Crystal Structure of Sterol Carrier Protein-2 like-3 (SCP2-L3) from Aedes Aegypti

PDB ID 3bks

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