1r41

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(New page: 200px<br /><applet load="1r41" size="450" color="white" frame="true" align="right" spinBox="true" caption="1r41, resolution 1.9&Aring;" /> '''Crystal structures of...)
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[[Image:1r41.gif|left|200px]]<br /><applet load="1r41" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1r41, resolution 1.9&Aring;" />
 
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'''Crystal structures of d(Gm5CGm5CGCGC) and d(GCGCGm5CGm5C): Effects of methylation on alternating DNA octamers'''<br />
 
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==Overview==
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==Crystal structures of d(Gm5CGm5CGCGC) and d(GCGCGm5CGm5C): Effects of methylation on alternating DNA octamers==
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The crystal structures of two alternating octamers d(Gm(5)CGm(5)CGCGC) and, d(GCGCGm(5)CGm(5)C) have been determined at 1.7 and 1.9 A resolution with, R(work)/R(free) of 16.9/19.6% and 17.9/19.8%, respectively. The two, octamers crystallized in the same tetragonal space group P4(3)2(1)2, with, unit-cell parameters a = b = 43.0, c = 24.9 A and a = b = 43.1, c = 24.7, A, respectively. Both structures adopt the A-type double helix and the, abutting crystal packing. Despite the different positions of the, methylated cytosine in the sequence, the two octamers display essentially, the same conformation. The close similarity of the two structures, indicates that methylation at different positions in a DNA sequence does, not affect the helical conformation of the alternating DNA octamer., Investigation of other related crystal structures implies that methylation, of cytosine stabilizes the A-type conformation for alternating DNA, sequences beginning with a 5'-purine but is beneficial to the Z-type, conformation for alternating DNA sequences beginning with a 5'-pyrimidine.
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<StructureSection load='1r41' size='340' side='right'caption='[[1r41]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1r41]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R41 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R41 FirstGlance]. <br>
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1R41 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1R41 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r41 OCA], [https://pdbe.org/1r41 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r41 RCSB], [https://www.ebi.ac.uk/pdbsum/1r41 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r41 ProSAT]</span></td></tr>
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Structures of d(Gm5)CGm5CGCGC) and d(GCGCGm5CGm5C): effects of methylation on alternating DNA octamers., Shi K, Pan B, Tippin D, Sundaralingam M, Acta Crystallogr D Biol Crystallogr. 2004 Jan;60(Pt 1):61-5. Epub 2003 Dec, 18. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14684893 14684893]
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</table>
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[[Category: Protein complex]]
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__TOC__
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[[Category: Pan, B.]]
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</StructureSection>
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[[Category: Shi, K.]]
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[[Category: Large Structures]]
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[[Category: Sundaralingam, M.]]
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[[Category: Pan B]]
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[[Category: Tippin, D.]]
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[[Category: Shi K]]
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[[Category: dna]]
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[[Category: Sundaralingam M]]
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[[Category: Tippin D]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 22:05:06 2007''
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Current revision

Crystal structures of d(Gm5CGm5CGCGC) and d(GCGCGm5CGm5C): Effects of methylation on alternating DNA octamers

PDB ID 1r41

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