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176d

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(New page: 200px<br /><applet load="176d" size="450" color="white" frame="true" align="right" spinBox="true" caption="176d" /> '''NMR SOLUTION STRUCTURE OF A PEPTIDE NUCLEIC ...)
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[[Image:176d.jpg|left|200px]]<br /><applet load="176d" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="176d" />
 
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'''NMR SOLUTION STRUCTURE OF A PEPTIDE NUCLEIC ACID COMPLEXED WITH RNA'''<br />
 
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==Overview==
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==NMR SOLUTION STRUCTURE OF A PEPTIDE NUCLEIC ACID COMPLEXED WITH RNA==
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Peptide nucleic acids (PNA) incorporating nucleic acid bases into an, achiral polyamide backbone bind to DNA in a sequence-dependent manner. The, structure of a PNA-ribonucleic acid (RNA) complex was determined with, nuclear magnetic resonance methods. A hexameric PNA formed a 1:1 complex, with a complementary RNA that is an antiparallel, right-handed double, helix with Watson-Crick base pairing similar to the "A" form structure of, RNA duplexes. The achiral PNA backbone assumed a distinct conformation, upon binding that differed from previously proposed models and provides a, basis for further structure-based design of antisense agents.
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<StructureSection load='176d' size='340' side='right'caption='[[176d]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[176d]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=176D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=176D FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=APN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-ADENINE'>APN</scene>, <scene name='pdbligand=CPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-CYTOSINE'>CPN</scene>, <scene name='pdbligand=GPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-GUANINE'>GPN</scene>, <scene name='pdbligand=TPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-THYMINE'>TPN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=176d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=176d OCA], [https://pdbe.org/176d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=176d RCSB], [https://www.ebi.ac.uk/pdbsum/176d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=176d ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Peptide nucleic acids (PNA) incorporating nucleic acid bases into an achiral polyamide backbone bind to DNA in a sequence-dependent manner. The structure of a PNA-ribonucleic acid (RNA) complex was determined with nuclear magnetic resonance methods. A hexameric PNA formed a 1:1 complex with a complementary RNA that is an antiparallel, right-handed double helix with Watson-Crick base pairing similar to the "A" form structure of RNA duplexes. The achiral PNA backbone assumed a distinct conformation upon binding that differed from previously proposed models and provides a basis for further structure-based design of antisense agents.
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==About this Structure==
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NMR solution structure of a peptide nucleic acid complexed with RNA.,Brown SC, Thomson SA, Veal JM, Davis DG Science. 1994 Aug 5;265(5173):777-80. PMID:7519361<ref>PMID:7519361</ref>
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176D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=176D OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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NMR solution structure of a peptide nucleic acid complexed with RNA., Brown SC, Thomson SA, Veal JM, Davis DG, Science. 1994 Aug 5;265(5173):777-80. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7519361 7519361]
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</div>
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[[Category: Protein complex]]
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<div class="pdbe-citations 176d" style="background-color:#fffaf0;"></div>
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[[Category: Brown, S.C.]]
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== References ==
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[[Category: Veal, J.M.]]
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<references/>
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[[Category: double helix]]
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__TOC__
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[[Category: nmr]]
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</StructureSection>
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[[Category: pna]]
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[[Category: Large Structures]]
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[[Category: rna]]
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[[Category: Brown SC]]
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[[Category: Veal JM]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 22:05:46 2007''
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Current revision

NMR SOLUTION STRUCTURE OF A PEPTIDE NUCLEIC ACID COMPLEXED WITH RNA

PDB ID 176d

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