3glf

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{{Seed}}
 
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[[Image:3glf.jpg|left|200px]]
 
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==Crystal Structure of the Ecoli Clamp Loader Bound to Primer-Template DNA==
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The line below this paragraph, containing "STRUCTURE_3glf", creates the "Structure Box" on the page.
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<StructureSection load='3glf' size='340' side='right'caption='[[3glf]], [[Resolution|resolution]] 3.39&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3glf]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. The June 2012 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Sliding Clamps'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2012_6 10.2210/rcsb_pdb/mom_2012_6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GLF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GLF FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.388&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3glf| PDB=3glf | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3glf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3glf OCA], [https://pdbe.org/3glf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3glf RCSB], [https://www.ebi.ac.uk/pdbsum/3glf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3glf ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HOLA_ECOLI HOLA_ECOLI] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gl/3glf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3glf ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of the Ecoli Clamp Loader Bound to Primer-Template DNA===
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==See Also==
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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3GLF is a 14 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GLF OCA].
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[[Category: Escherichia coli K-12]]
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[[Category: DNA-directed DNA polymerase]]
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[[Category: Large Structures]]
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[[Category: Escherichia coli]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Kuriyan, J.]]
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[[Category: Sliding Clamps]]
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[[Category: Simonetta, K R.]]
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[[Category: Kuriyan J]]
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[[Category: Aaa+ atpase]]
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[[Category: Simonetta KR]]
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[[Category: Atp-binding]]
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[[Category: Clamp loader]]
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[[Category: Dna replication]]
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[[Category: Dna-directed dna polymerase]]
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[[Category: Gamma complex]]
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[[Category: Nucleotide-binding]]
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[[Category: Nucleotidyltransferase]]
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[[Category: Replication]]
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[[Category: Ribosomal frameshifting]]
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[[Category: Transferase]]
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[[Category: Transferase/dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 27 15:23:37 2009''
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Current revision

Crystal Structure of the Ecoli Clamp Loader Bound to Primer-Template DNA

PDB ID 3glf

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