3gjx

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{{Seed}}
 
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[[Image:3gjx.jpg|left|200px]]
 
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==Crystal Structure of the Nuclear Export Complex CRM1-Snurportin1-RanGTP==
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The line below this paragraph, containing "STRUCTURE_3gjx", creates the "Structure Box" on the page.
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<StructureSection load='3gjx' size='340' side='right'caption='[[3gjx]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3gjx]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GJX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GJX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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{{STRUCTURE_3gjx| PDB=3gjx | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gjx OCA], [https://pdbe.org/3gjx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gjx RCSB], [https://www.ebi.ac.uk/pdbsum/3gjx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gjx ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SPN1_HUMAN SPN1_HUMAN] Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.<ref>PMID:9670026</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gj/3gjx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gjx ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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CRM1 mediates nuclear export of numerous unrelated cargoes, which may carry a short leucine-rich nuclear export signal or export signatures that include folded domains. How CRM1 recognizes such a variety of cargoes has been unknown up to this point. Here we present the crystal structure of the SPN1.CRM1.RanGTP export complex at 2.5 angstrom resolution (where SPN1 is snurportin1 and RanGTP is guanosine 5' triphosphate-bound Ran). SPN1 is a nuclear import adapter for cytoplasmically assembled, m(3)G-capped spliceosomal U snRNPs (small nuclear ribonucleoproteins). The structure shows how CRM1 can specifically return the cargo-free form of SPN1 to the cytoplasm. The extensive contact area includes five hydrophobic residues at the SPN1 amino terminus that dock into a hydrophobic cleft of CRM1, as well as numerous hydrophilic contacts of CRM1 to m(3)G cap-binding domain and carboxyl-terminal residues of SPN1. The structure suggests that RanGTP promotes cargo-binding to CRM1 solely through long-range conformational changes in the exportin.
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===Crystal Structure of the Nuclear Export Complex CRM1-Snurportin1-RanGTP===
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Crystal structure of the nuclear export receptor CRM1 in complex with Snurportin1 and RanGTP.,Monecke T, Guttler T, Neumann P, Dickmanns A, Gorlich D, Ficner R Science. 2009 May 22;324(5930):1087-91. Epub 2009 Apr 23. PMID:19389996<ref>PMID:19389996</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3gjx" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19389996}}, adds the Publication Abstract to the page
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*[[Exportin 3D structures|Exportin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19389996 is the PubMed ID number.
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*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
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== References ==
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{{ABSTRACT_PUBMED_19389996}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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3GJX is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GJX OCA].
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==Reference==
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<ref group="xtra">PMID:19389996</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Dickmanns, A.]]
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[[Category: Dickmanns A]]
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[[Category: Ficner, R.]]
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[[Category: Ficner R]]
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[[Category: Goerlich, D.]]
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[[Category: Goerlich D]]
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[[Category: Guettler, T.]]
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[[Category: Guettler T]]
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[[Category: Monecke, T.]]
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[[Category: Monecke T]]
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[[Category: Neumann, P.]]
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[[Category: Neumann P]]
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[[Category: Acetylation]]
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[[Category: Cytoplasm]]
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[[Category: Gtp-binding]]
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[[Category: Host-virus interaction]]
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[[Category: Mrna transport]]
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[[Category: Nucleotide-binding]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Protein transport]]
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[[Category: Rna-binding]]
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[[Category: Transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 27 15:23:39 2009''
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Current revision

Crystal Structure of the Nuclear Export Complex CRM1-Snurportin1-RanGTP

PDB ID 3gjx

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