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187d

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(New page: 200px<br /><applet load="187d" size="450" color="white" frame="true" align="right" spinBox="true" caption="187d, resolution 2.250&Aring;" /> '''HYDRATION PATTERNS ...)
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[[Image:187d.gif|left|200px]]<br /><applet load="187d" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="187d, resolution 2.250&Aring;" />
 
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'''HYDRATION PATTERNS AND INTERMOLECULAR INTERACTIONS IN A-DNA CRYSTAL STRUCTURES. IMPLICATIONS FOR DNA RECOGNITION'''<br />
 
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==Overview==
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==HYDRATION PATTERNS AND INTERMOLECULAR INTERACTIONS IN A-DNA CRYSTAL STRUCTURES. IMPLICATIONS FOR DNA RECOGNITION==
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Crystallographic studies of DNA fragments of the A and B conformations, have shown that the structure and hydration of the DNA double helix depend, both on the base sequence and the environment. Detailed analyses of, solvent organization in DNA crystals and its role in intermolecular, interactions have been reported mainly for B-DNA structures. We have, determined the crystal structures of several isomorphous A-DNA octamers at, resolutions from 1.8 to 2.5 A and refined them by the same procedure., Comparative analysis of five independently refined structures in terms of, hydration and intermolecular interactions has been performed leading to, the following findings. The A-DNA major groove is extensively hydrated and, together with the hydration shells of the sugar-phosphate backbone can, form an ordered network of fused polygons. The water structure of the, phosphate backbone is less conserved than that of the grooves., Characteristic hydration patterns are associated with specific base, sequences. The A-DNA minor groove provides sites for intermolecular, contacts through hydrophobic and polar interactions. Well-ordered water, molecules mediate interduplex interactions that involve either the grooves, or the backbone, or both. The direct and water-mediated intermolecular, interactions observed in the A-DNA crystal structures are relevant to, various recognition motifs between DNA and other molecules. In particular, intermolecular interactions at the DNA minor groove are analogous to those, observed in the recently reported crystal structures of complexes between, the TATA-binding protein and the TATA-box.
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<StructureSection load='187d' size='340' side='right'caption='[[187d]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[187d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=187D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=187D FirstGlance]. <br>
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187D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=187D OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=187d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=187d OCA], [https://pdbe.org/187d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=187d RCSB], [https://www.ebi.ac.uk/pdbsum/187d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=187d ProSAT]</span></td></tr>
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==Reference==
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</table>
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Hydration patterns and intermolecular interactions in A-DNA crystal structures. Implications for DNA recognition., Eisenstein M, Shakked Z, J Mol Biol. 1995 May 5;248(3):662-78. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7752232 7752232]
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__TOC__
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[[Category: Protein complex]]
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</StructureSection>
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[[Category: Eisenstein, M.]]
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[[Category: Large Structures]]
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[[Category: Shakked, Z.]]
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[[Category: Eisenstein M]]
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[[Category: a-dna]]
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[[Category: Shakked Z]]
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[[Category: double helix]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 22:09:51 2007''
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Current revision

HYDRATION PATTERNS AND INTERMOLECULAR INTERACTIONS IN A-DNA CRYSTAL STRUCTURES. IMPLICATIONS FOR DNA RECOGNITION

PDB ID 187d

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