3etu

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{{Seed}}
 
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[[Image:3etu.png|left|200px]]
 
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==Crystal structure of yeast Dsl1p==
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The line below this paragraph, containing "STRUCTURE_3etu", creates the "Structure Box" on the page.
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<StructureSection load='3etu' size='340' side='right'caption='[[3etu]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3etu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ETU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ETU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3etu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3etu OCA], [https://pdbe.org/3etu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3etu RCSB], [https://www.ebi.ac.uk/pdbsum/3etu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3etu ProSAT]</span></td></tr>
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{{STRUCTURE_3etu| PDB=3etu | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DSL1_YEAST DSL1_YEAST] Required for protein transport between the Golgi and the endoplasmic reticulum. May tether coatomer-coated retrograde transport vesicles to the ER membrane through interaction with coatomer as well as the SNARE complex. May contribute to the stabilization of the SNARE complex.<ref>PMID:11260526</ref> <ref>PMID:11493604</ref> <ref>PMID:11739780</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Multisubunit tethering complexes are essential for intracellular trafficking and have been proposed to mediate the initial interaction between vesicles and the membranes with which they fuse. Here we report initial structural characterization of the Dsl1p complex, whose three subunits are essential for trafficking from the Golgi apparatus to the endoplasmic reticulum (ER). Crystal structures reveal that two of the three subunits, Tip20p and Dsl1p, resemble known subunits of the exocyst complex, establishing a structural connection among several multisubunit tethering complexes and implying that many of their subunits are derived from a common progenitor. We show, moreover, that Tip20p and Dsl1p interact directly via N-terminal alpha-helices. Finally, we establish that different Dsl1p complex subunits bind independently to different ER SNARE proteins. Our results map out two alternative protein-interaction networks capable of tethering COPI-coated vesicles, via the Dsl1p complex, to ER membranes.
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===Crystal structure of yeast Dsl1p===
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Structural characterization of Tip20p and Dsl1p, subunits of the Dsl1p vesicle tethering complex.,Tripathi A, Ren Y, Jeffrey PD, Hughson FM Nat Struct Mol Biol. 2009 Feb;16(2):114-23. Epub 2009 Jan 18. PMID:19151722<ref>PMID:19151722</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 3etu" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19151722 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19151722}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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3ETU is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ETU OCA].
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==Reference==
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<ref group="xtra">PMID:19151722</ref><references group="xtra"/>
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Hughson, F M.]]
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[[Category: Hughson FM]]
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[[Category: Jeffrey, P D.]]
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[[Category: Jeffrey PD]]
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[[Category: Ren, Y.]]
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[[Category: Ren Y]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Er-golgi transport]]
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[[Category: Helical bundle]]
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[[Category: Membrane]]
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[[Category: Phosphoprotein]]
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[[Category: Protein transport]]
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[[Category: Transport]]
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[[Category: Transport protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 3 08:42:14 2009''
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Current revision

Crystal structure of yeast Dsl1p

PDB ID 3etu

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