2bve

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{{Seed}}
 
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[[Image:2bve.png|left|200px]]
 
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==Structure of the N-terminal of Sialoadhesin in complex with 2-Phenyl- Prop5Ac==
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The line below this paragraph, containing "STRUCTURE_2bve", creates the "Structure Box" on the page.
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<StructureSection load='2bve' size='340' side='right'caption='[[2bve]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2bve]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BVE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BVE FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PH5:2-PHENYL-PROP5AC'>PH5</scene></td></tr>
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{{STRUCTURE_2bve| PDB=2bve | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bve OCA], [https://pdbe.org/2bve PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bve RCSB], [https://www.ebi.ac.uk/pdbsum/2bve PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bve ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SN_MOUSE SN_MOUSE] Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells (By similarity). Preferentially binds to alpha-2,3-linked sialic acid. Binds to SPN/CD43 on T-cells. May play a role in hematopoiesis. May act as a counter-receptor for CLEC10A in lymph node.<ref>PMID:15364954</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bv/2bve_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bve ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The Siglec family of receptors mediates cell-surface interactions through recognition of sialylated glycoconjugates. Previously reported structures of the N-terminal domain of the Siglec sialoadhesin (SnD1) in complex with various sialic acid analogs revealed the structural template for sialic acid binding. To characterize further the carbohydrate-binding properties, we have determined the crystal structures of SnD1 in the absence of ligand, and in complex with 2-benzyl-Neu5NPro and 2-benzyl-Neu5NAc. These structures reveal that SnD1 undergoes very few structural changes on ligand binding and detail how two novel classes of sialic acid analogs bind, one of which unexpectedly can induce Siglec dimerization. In conjunction with in silico analysis, this set of structures informs us about the design of putative ligands with enhanced binding affinities and specificities to different Siglecs, and provides data with which to test the effectiveness of different computational drug design protocols.
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===STRUCTURE OF THE N-TERMINAL OF SIALOADHESIN IN COMPLEX WITH 2-PHENYL-PROP5AC===
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Crystallographic and in silico analysis of the sialoside-binding characteristics of the Siglec sialoadhesin.,Zaccai NR, May AP, Robinson RC, Burtnick LD, Crocker PR, Brossmer R, Kelm S, Jones EY J Mol Biol. 2007 Feb 2;365(5):1469-79. Epub 2006 Oct 28. PMID:17137591<ref>PMID:17137591</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17137591}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2bve" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17137591 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17137591}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2BVE is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BVE OCA].
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==Reference==
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<ref group="xtra">PMID:17137591</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Brossmer, R.]]
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[[Category: Brossmer R]]
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[[Category: Burtnick, L D.]]
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[[Category: Burtnick LD]]
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[[Category: Crocker, P.]]
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[[Category: Crocker P]]
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[[Category: Jones, E Y.]]
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[[Category: Jones EY]]
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[[Category: Kelm, S.]]
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[[Category: Kelm S]]
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[[Category: May, A P.]]
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[[Category: May AP]]
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[[Category: Robinson, R C.]]
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[[Category: Robinson RC]]
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[[Category: Zaccai, N R.]]
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[[Category: Zaccai NR]]
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[[Category: Carbohydrate binding]]
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[[Category: Cell adhesion]]
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[[Category: Immune system]]
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[[Category: Immunoglobulin]]
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[[Category: Inhibitor design]]
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[[Category: Lectin]]
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[[Category: Siglec]]
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[[Category: Superfamily]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 3 08:46:14 2009''
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Current revision

Structure of the N-terminal of Sialoadhesin in complex with 2-Phenyl- Prop5Ac

PDB ID 2bve

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