3d6l

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{{Seed}}
 
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[[Image:3d6l.png|left|200px]]
 
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==Crystal structure of Cj0915, a hexameric hotdog fold thioesterase of Campylobacter jejuni==
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The line below this paragraph, containing "STRUCTURE_3d6l", creates the "Structure Box" on the page.
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<StructureSection load='3d6l' size='340' side='right'caption='[[3d6l]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3d6l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Campylobacter_jejuni Campylobacter jejuni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D6L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D6L FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.59&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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{{STRUCTURE_3d6l| PDB=3d6l | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d6l OCA], [https://pdbe.org/3d6l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d6l RCSB], [https://www.ebi.ac.uk/pdbsum/3d6l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d6l ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q0P9Y4_CAMJE Q0P9Y4_CAMJE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d6/3d6l_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3d6l ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Acyl-coenzyme A (CoA) thioesterases are a large family of enzymes that hydrolyze acyl-CoA esters to the free fatty acid and CoA and thereby regulate essential cellular functions such as lipid metabolism, membrane synthesis, signal transduction, and gene transcription. To better understand the virulence mechanisms of Campylobacter jejuni, and its possible link to membrane lipid biosynthesis, we have investigated C. jejuni thioesterases, annotated as putative proteins. While little is known about fatty acid biosynthesis and regulation in C. jejuni, remarkable differences in the genome and its organization from Escherichia coli, the paradigm system, raise questions as to the functions of these putative proteins. Here we present the crystal structure and biochemical analysis of Cj0915, defining the first functional thioesterase from C. jejuni. The structure of Cj0915 reveals the hot dog fold with an YciA-type hexameric assembly. Enzymatic assays performed with the purified protein show that Cj0915 is an efficient thioesterase with a broad specificity toward acyl-CoA substrates. This study provides a framework for investigation on roles of the Cj0915 thioesterase in virulence, and functional activities associated with the Cj0915 thioesterase in vivo.
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===Crystal structure of Cj0915, a hexameric hotdog fold thioesterase of Campylobacter jejuni===
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Structure and function of a Campylobacter jejuni thioesterase Cj0915, a hexameric hot dog fold enzyme.,Yokoyama T, Choi KJ, Bosch AM, Yeo HJ Biochim Biophys Acta. 2009 Jul;1794(7):1073-81. Epub 2009 Mar 17. PMID:19303060<ref>PMID:19303060</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19303060}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3d6l" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19303060 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19303060}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3D6L is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Campylobacter_jejuni Campylobacter jejuni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D6L OCA].
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==Reference==
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<ref group="xtra">PMID:19303060</ref><references group="xtra"/>
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[[Category: Campylobacter jejuni]]
[[Category: Campylobacter jejuni]]
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[[Category: Yeo, H J.]]
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[[Category: Large Structures]]
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[[Category: Yokoyama, T.]]
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[[Category: Yeo HJ]]
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[[Category: Acyl-coa]]
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[[Category: Yokoyama T]]
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[[Category: Campylobacter jejuni]]
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[[Category: Hot dog fold]]
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[[Category: Hydrolase]]
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[[Category: Thioesterase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 3 09:09:57 2009''
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Current revision

Crystal structure of Cj0915, a hexameric hotdog fold thioesterase of Campylobacter jejuni

PDB ID 3d6l

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