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1r68

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(New page: 200px<br /><applet load="1r68" size="450" color="white" frame="true" align="right" spinBox="true" caption="1r68, resolution 1.20&Aring;" /> '''Role of the amino su...)
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[[Image:1r68.gif|left|200px]]<br /><applet load="1r68" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1r68, resolution 1.20&Aring;" />
 
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'''Role of the amino sugar in DNA binding of disaccharide anthracyclines: crystal structure of MAR70/d(CGATCG) complex'''<br />
 
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==Overview==
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==Role of the amino sugar in DNA binding of disaccharide anthracyclines: crystal structure of MAR70/d(CGATCG) complex==
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Disaccharide anthracyclines analogues have been shown to exhibit different, antitumour activity as compared with parents compounds doxorubicin and, daunomycin. Here we report the crystal structure of the disaccharide, analog MAR70 complexed with the DNA hexamer d(CGATCG). The structure has, been solved at 1.54A resolution and is similar to previous crystallized, anthracycline-DNA complexes with both sugar rings of the disaccharide, chain lying in the DNA minor groove. Comparison with the structure of, MEN10755 another disaccharide anthracycline co-crystallized with the same, DNA hexamer suggests a correlation between the position of the amino sugar, on the disaccharide chain and the conformation of this moiety when binding, to DNA. This is discussed with respect to the influence on drug activity, and on the possible interaction with other cellular targets.
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<StructureSection load='1r68' size='340' side='right'caption='[[1r68]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1r68]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R68 FirstGlance]. <br>
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1R68 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with MAR as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1R68 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MAR:4-EPI-4-(2-DEOXYFUCOSE)DAUNOMYCIN'>MAR</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r68 OCA], [https://pdbe.org/1r68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r68 RCSB], [https://www.ebi.ac.uk/pdbsum/1r68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r68 ProSAT]</span></td></tr>
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Role of the amino sugar in the DNA binding of disaccharide anthracyclines: crystal structure of the complex MAR70/d(CGATCG)., Temperini C, Cirilli M, Aschi M, Ughetto G, Bioorg Med Chem. 2005 Mar 1;13(5):1673-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15698785 15698785]
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</table>
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[[Category: Protein complex]]
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__TOC__
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[[Category: Aschi, M.]]
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</StructureSection>
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[[Category: Cirilli, M.]]
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[[Category: Large Structures]]
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[[Category: Temperini, C.]]
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[[Category: Aschi M]]
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[[Category: Ughetto, G.]]
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[[Category: Cirilli M]]
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[[Category: MAR]]
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[[Category: Temperini C]]
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[[Category: double helix]]
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[[Category: Ughetto G]]
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[[Category: drug-dna complex]]
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[[Category: right handed dna]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 22:13:37 2007''
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Current revision

Role of the amino sugar in DNA binding of disaccharide anthracyclines: crystal structure of MAR70/d(CGATCG) complex

PDB ID 1r68

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