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2vw9

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{{Seed}}
 
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[[Image:2vw9.jpg|left|200px]]
 
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<!--
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==Single stranded DNA binding protein complex from Helicobacter pylori==
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The line below this paragraph, containing "STRUCTURE_2vw9", creates the "Structure Box" on the page.
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<StructureSection load='2vw9' size='340' side='right'caption='[[2vw9]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2vw9]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori_26695 Helicobacter pylori 26695]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VW9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VW9 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vw9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vw9 OCA], [https://pdbe.org/2vw9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vw9 RCSB], [https://www.ebi.ac.uk/pdbsum/2vw9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vw9 ProSAT]</span></td></tr>
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{{STRUCTURE_2vw9| PDB=2vw9 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SSB_HELPY SSB_HELPY] Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vw/2vw9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vw9 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Single-stranded DNA (ssDNA)-binding protein (SSB) plays an important role in DNA replication, recombination, and repair. SSB consists of an N-terminal ssDNA-binding domain with an oligonucleotide/oligosaccharide binding fold and a flexible C-terminal tail involved in protein-protein interactions. SSB from Helicobacter pylori (HpSSB) was isolated, and the ssDNA-binding characteristics of HpSSB were analyzed by fluorescence titration and electrophoretic mobility shift assay. Tryptophan fluorescence quenching was measured as 61%, and the calculated cooperative affinity was 5.4x10(7) M(-1) with an ssDNA-binding length of 25-30 nt. The crystal structure of the C-terminally truncated protein (HpSSBc) in complex with 35-mer ssDNA [HpSSBc-(dT)(35)] was determined at a resolution of 2.3 A. The HpSSBc monomer folds as an oligonucleotide/oligosaccharide binding fold with a Y-shaped conformation. The ssDNA wrapped around the HpSSBc tetramer through a continuous binding path comprising five essential aromatic residues and a positively charged surface formed by numerous basic residues.
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===SINGLE STRANDED DNA BINDING PROTEIN COMPLEX FROM HELICOBACTER PYLORI===
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Single-stranded DNA-binding protein complex from Helicobacter pylori suggests an ssDNA-binding surface.,Chan KW, Lee YJ, Wang CH, Huang H, Sun YJ J Mol Biol. 2009 May 8;388(3):508-19. Epub 2009 Mar 13. PMID:19285993<ref>PMID:19285993</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2vw9" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19285993}}, adds the Publication Abstract to the page
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*[[Single-stranded DNA-binding protein 3D structures|Single-stranded DNA-binding protein 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19285993 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19285993}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Helicobacter pylori 26695]]
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2VW9 is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VW9 OCA].
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[[Category: Large Structures]]
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[[Category: Chan K-W]]
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==Reference==
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[[Category: Lee Y-J]]
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<ref group="xtra">PMID:19285993</ref><references group="xtra"/>
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[[Category: Sun Y-J]]
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[[Category: Helicobacter pylori]]
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[[Category: Wang C-H]]
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[[Category: Chan, K W.]]
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[[Category: Lee, Y J.]]
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[[Category: Sun, Y J.]]
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[[Category: Wang, C H.]]
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[[Category: Dna damage]]
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[[Category: Dna repair]]
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[[Category: Dna replication]]
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[[Category: Dna-binding protein]]
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[[Category: Helicobacter pylori]]
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[[Category: Ob-fold]]
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[[Category: Oligonucleotide/oligosaccharide binding fold]]
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[[Category: Single-stranded dna]]
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[[Category: Single-stranded dna binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 4 07:23:33 2009''
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Current revision

Single stranded DNA binding protein complex from Helicobacter pylori

PDB ID 2vw9

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