2obm

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{{Seed}}
 
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[[Image:2obm.png|left|200px]]
 
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==Structural and biochemical analysis of a prototypical ATPase from the type III secretion system of pathogenic bacteria==
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The line below this paragraph, containing "STRUCTURE_2obm", creates the "Structure Box" on the page.
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<StructureSection load='2obm' size='340' side='right'caption='[[2obm]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2obm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O127:H6_str._E2348/69 Escherichia coli O127:H6 str. E2348/69]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OBM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OBM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_2obm| PDB=2obm | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2obm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2obm OCA], [https://pdbe.org/2obm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2obm RCSB], [https://www.ebi.ac.uk/pdbsum/2obm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2obm ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/B7UMA6_ECO27 B7UMA6_ECO27]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ob/2obm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2obm ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The type III secretion system (T3SS) ATPase is the conserved and essential inner-membrane component involved in the initial stages of selective secretion of specialized T3SS virulence effector proteins from the bacterial cytoplasm through to the infected host cell, a process crucial to subsequent pathogenicity. Here we present the 1.8-A-resolution crystal structure of the catalytic domain of the prototypical T3SS ATPase EscN from enteropathogenic Escherichia coli (EPEC). Along with in vitro and in vivo mutational analysis, our data show that the T3SS ATPases share similarity with the F1 ATPases but have important structural and sequence differences that dictate their unique secretory role. We also show that T3SS ATPase activity is dependent on EscN oligomerization and describe the molecular features and possible functional implications of a hexameric ring model.
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===Structural and biochemical analysis of a prototypical ATPase from the type III secretion system of pathogenic bacteria===
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Structural analysis of a prototypical ATPase from the type III secretion system.,Zarivach R, Vuckovic M, Deng W, Finlay BB, Strynadka NC Nat Struct Mol Biol. 2007 Feb;14(2):131-7. Epub 2007 Jan 21. PMID:17237797<ref>PMID:17237797</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17237797}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2obm" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17237797 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17237797}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Escherichia coli O127:H6 str. E2348/69]]
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2OBM is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Bacteria Bacteria]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OBM OCA].
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[[Category: Large Structures]]
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[[Category: Deng W]]
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==Reference==
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[[Category: Finlay BB]]
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<ref group="xtra">PMID:17237797</ref><references group="xtra"/>
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[[Category: Strynadka NCJ]]
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[[Category: Bacteria]]
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[[Category: Vuckovic M]]
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[[Category: Deng, W.]]
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[[Category: Zarivach R]]
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[[Category: Finlay, B B.]]
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[[Category: Strynadka, N C.J.]]
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[[Category: Vuckovic, M.]]
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[[Category: Zarivach, R.]]
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[[Category: Atpase]]
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[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 4 07:38:18 2009''
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Current revision

Structural and biochemical analysis of a prototypical ATPase from the type III secretion system of pathogenic bacteria

PDB ID 2obm

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