1n7a

[[Image:1n7a.gif|left|200px]]<br /><applet load="1n7a" size="450" color="white" frame="true" align="right" spinBox="true"

caption="1n7a, resolution 1.20&Aring;" />

'''RIP-Radiation-damage Induced Phasing'''<br />

==Overview==

The use of third generation synchrotron sources has led to renewed concern, about the effect of ionizing radiation on crystalline biological samples., In general, the problem is seen as one to be avoided. However, in this, paper, it is shown that, far from being a hindrance to successful, structure determination, radiation damage provides an opportunity for, phasing macromolecular structures. This is successfully demonstrated for, both a protein and an oligonucleotide, by way of which complete models, were built automatically. The possibility that, through the exploitation, of radiation damage, the phase problem could become less of a barrier to, macromolecular crystal structure determination is discussed.

 

==About this Structure==

1N7A is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with K and SPM as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1N7A OCA].

 

Specific radiation damage can be used to solve macromolecular crystal structures., Ravelli RB, Leiros HK, Pan B, Caffrey M, McSweeney S, Structure. 2003 Feb;11(2):217-24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12575941 12575941]

[[Category: Protein complex]]

[[Category: Caffrey, M.]]

[[Category: Leiros, H.K.S.]]

[[Category: McSweeney, S.]]

[[Category: Pan, B.]]

[[Category: Ravelli, R.B.G.]]