1afx

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(New page: 200px<br /><applet load="1afx" size="450" color="white" frame="true" align="right" spinBox="true" caption="1afx" /> '''UGAA EUKARYOTIC RIBOSOMAL RNA TETRALOOP, NMR...)
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'''UGAA EUKARYOTIC RIBOSOMAL RNA TETRALOOP, NMR, 13 STRUCTURES'''<br />
 
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==Overview==
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==UGAA EUKARYOTIC RIBOSOMAL RNA TETRALOOP, NMR, 13 STRUCTURES==
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The hairpin ribozyme is a small catalytic RNA with a unique two-domain, structure. Here we present the solution structure of the loop B domain of, the hairpin ribozyme, which contains most of the catalytically essential, nucleotides. The 38-nucleotide domain contains a 16-nucleotide internal, loop that forms one of the largest non-Watson-Crick segments of base, pairing thus far determined by either NMR or crystallography. Since the, solution structure of the smaller loop A domain has been previously, solved, an NMR structure-based model of the 22,000 Mr hairpin, ribozyme-substrate open complex emerges by joining the two domain, structures. Strikingly, catalytically essential functional groups for the, loop B domain are concentrated within an expanded minor groove, presenting, a clear docking surface for the loop A domain.
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<StructureSection load='1afx' size='340' side='right'caption='[[1afx]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1afx]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AFX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AFX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1afx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1afx OCA], [https://pdbe.org/1afx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1afx RCSB], [https://www.ebi.ac.uk/pdbsum/1afx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1afx ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The hairpin ribozyme is a small catalytic RNA with a unique two-domain structure. Here we present the solution structure of the loop B domain of the hairpin ribozyme, which contains most of the catalytically essential nucleotides. The 38-nucleotide domain contains a 16-nucleotide internal loop that forms one of the largest non-Watson-Crick segments of base pairing thus far determined by either NMR or crystallography. Since the solution structure of the smaller loop A domain has been previously solved, an NMR structure-based model of the 22,000 Mr hairpin ribozyme-substrate open complex emerges by joining the two domain structures. Strikingly, catalytically essential functional groups for the loop B domain are concentrated within an expanded minor groove, presenting a clear docking surface for the loop A domain.
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==About this Structure==
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Solution structure of the loop B domain from the hairpin ribozyme.,Butcher SE, Allain FH, Feigon J Nat Struct Biol. 1999 Mar;6(3):212-6. PMID:10074938<ref>PMID:10074938</ref>
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1AFX is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AFX OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Solution structure of the loop B domain from the hairpin ribozyme., Butcher SE, Allain FH, Feigon J, Nat Struct Biol. 1999 Mar;6(3):212-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10074938 10074938]
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</div>
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[[Category: Protein complex]]
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<div class="pdbe-citations 1afx" style="background-color:#fffaf0;"></div>
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[[Category: Butcher, S.E.]]
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== References ==
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[[Category: Dieckmann, T.]]
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<references/>
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[[Category: Feigon, J.]]
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__TOC__
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[[Category: ribonucleic acid]]
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</StructureSection>
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[[Category: ribosomal rna]]
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[[Category: Large Structures]]
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[[Category: tetraloop]]
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[[Category: Butcher SE]]
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[[Category: Dieckmann T]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 22:47:37 2007''
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[[Category: Feigon J]]

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UGAA EUKARYOTIC RIBOSOMAL RNA TETRALOOP, NMR, 13 STRUCTURES

PDB ID 1afx

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