3ewg

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (15:23, 1 November 2023) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3ewg.jpg|left|200px]]
 
-
<!--
+
==Crystal structure of the N-terminal domain of NusG (NGN) from Methanocaldococcus jannaschii==
-
The line below this paragraph, containing "STRUCTURE_3ewg", creates the "Structure Box" on the page.
+
<StructureSection load='3ewg' size='340' side='right'caption='[[3ewg]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3ewg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EWG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EWG FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.04&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene></td></tr>
-
{{STRUCTURE_3ewg| PDB=3ewg | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ewg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ewg OCA], [https://pdbe.org/3ewg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ewg RCSB], [https://www.ebi.ac.uk/pdbsum/3ewg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ewg ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/SPT5_METJA SPT5_METJA] Stimulates transcription elongation.[HAMAP-Rule:MF_00950]<ref>PMID:20197319</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ew/3ewg_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ewg ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Transcription in archaea employs a eukaryotic-type transcription apparatus but uses bacterial-type transcription factors. NusG is one of the few archaeal transcription factors whose orthologs are essential in both bacteria and eukaryotes. Archaeal NusG is composed of only an NusG N-terminal (NGN) domain and a KOW domain, which is similar to bacterial NusG but not to the eukaryotic ortholog, Spt5. However, archaeal NusG was confirmed recently to form a complex with rpoE'' that was similar to the Spt5-Spt4 complex. Thus, archaeal NusG presents hybrid features of Spt5 and bacterial NusG. Here we report the crystal structure of NGN from the archaea Methanocaldococcus jannaschii (MjNGN). MjNGN folds to an alpha-beta-alpha sandwich without the appendant domain of bacterial NGNs, and forms a unique homodimer in crystal and solution. MjNGN alone was found to be sufficient for rpoE'' binding and an MjNGN-rpoE'' model has been constructed by rigid docking. Proteins 2009. (c) 2009 Wiley-Liss, Inc.
-
===Crystal structure of the N-terminal domain of NusG (NGN) from Methanocaldococcus jannaschii===
+
Crystal structure of NusG N-terminal (NGN) domain from Methanocaldococcus jannaschii and its interaction with rpoE'',Zhou H, Liu Q, Gao Y, Teng M, Niu L Proteins. 2009 Apr 28. PMID:19475703<ref>PMID:19475703</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_19475703}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 3ewg" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 19475703 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_19475703}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
3EWG is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EWG OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:19475703</ref><references group="xtra"/>
+
[[Category: Methanocaldococcus jannaschii]]
[[Category: Methanocaldococcus jannaschii]]
-
[[Category: Gao, Y X.]]
+
[[Category: Gao YX]]
-
[[Category: Liu, Q.]]
+
[[Category: Liu Q]]
-
[[Category: Niu, L W.]]
+
[[Category: Niu LW]]
-
[[Category: Teng, M K.]]
+
[[Category: Teng MK]]
-
[[Category: Zhou, H H.]]
+
[[Category: Zhou HH]]
-
[[Category: Alpha/beta structure]]
+
-
[[Category: Antiparallel beta sheet]]
+
-
[[Category: Flanked alpha helice]]
+
-
[[Category: Transcription]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 17 10:07:20 2009''
+

Current revision

Crystal structure of the N-terminal domain of NusG (NGN) from Methanocaldococcus jannaschii

PDB ID 3ewg

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3ewg"
Personal tools