3he1

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{{Seed}}
 
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[[Image:3he1.jpg|left|200px]]
 
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==Secreted protein Hcp3 from Pseudomonas aeruginosa.==
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The line below this paragraph, containing "STRUCTURE_3he1", creates the "Structure Box" on the page.
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<StructureSection load='3he1' size='340' side='right'caption='[[3he1]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3he1]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HE1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HE1 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.098&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_3he1| PDB=3he1 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3he1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3he1 OCA], [https://pdbe.org/3he1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3he1 RCSB], [https://www.ebi.ac.uk/pdbsum/3he1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3he1 ProSAT], [https://www.topsan.org/Proteins/MCSG/3he1 TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MAJE_PSEAE MAJE_PSEAE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/he/3he1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3he1 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The Type VI secretion pathway transports proteins across the cell envelope of Gram-negative bacteria. Pseudomonas aeruginosa, an opportunistic Gram-negative bacterial pathogen infecting humans, uses the type VI secretion pathway to export specific effector proteins crucial for its pathogenesis. The HSI-I virulence locus encodes for several proteins that has been proposed to participate in protein transport including the Hcp1 protein, which forms hexameric rings that assemble into nanotubes in vitro. Two Hcp1 paralogues have been identified in the P. aeruginosa genome, Hsp2 and Hcp3. Here, we present the structure of the Hcp3 protein from P. aeruginosa. The overall structure of the monomer resembles Hcp1 despite the lack of amino-acid sequence similarity between the two proteins. The monomers assemble into hexamers similar to Hcp1. However, instead of forming nanotubes in head-to-tail mode like Hcp1, Hcp3 stacks its rings in head-to-head mode forming double-ring structures.
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===Secreted protein Hcp3 from Pseudomonas aeruginosa.===
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Crystal structure of secretory protein Hcp3 from Pseudomonas aeruginosa.,Osipiuk J, Xu X, Cui H, Savchenko A, Edwards A, Joachimiak A J Struct Funct Genomics. 2011 Mar;12(1):21-6. Epub 2011 Apr 8. PMID:21476004<ref>PMID:21476004</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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3HE1 is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HE1 OCA].
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<div class="pdbe-citations 3he1" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
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[[Category: Cui, H.]]
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[[Category: Cui H]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards AM]]
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[[Category: Joachimiak, A.]]
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[[Category: Joachimiak A]]
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[[Category: MCSG, Midwest Center for Structural Genomics.]]
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[[Category: Osipiuk J]]
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[[Category: Osipiuk, J.]]
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[[Category: Savchenko A]]
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[[Category: Savchenko, A.]]
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[[Category: Xu X]]
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[[Category: Xu, X.]]
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[[Category: Apc22128]]
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[[Category: Hcp3]]
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[[Category: Hcpc]]
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[[Category: Mcsg]]
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[[Category: Midwest center for structural genomic]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Secreted]]
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[[Category: Secretion]]
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[[Category: Structural genomic]]
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[[Category: Unknown function]]
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[[Category: Virulence]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 17 11:33:31 2009''
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Current revision

Secreted protein Hcp3 from Pseudomonas aeruginosa.

PDB ID 3he1

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OCA

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