3hof

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{{Seed}}
 
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[[Image:3hof.jpg|left|200px]]
 
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==Structure of macrophage migration inhibitory factor (MIF) with caffeic acid at 1.9A resolution==
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The line below this paragraph, containing "STRUCTURE_3hof", creates the "Structure Box" on the page.
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<StructureSection load='3hof' size='340' side='right'caption='[[3hof]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3hof]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HOF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HOF FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DHC:CAFFEIC+ACID'>DHC</scene></td></tr>
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{{STRUCTURE_3hof| PDB=3hof | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hof OCA], [https://pdbe.org/3hof PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hof RCSB], [https://www.ebi.ac.uk/pdbsum/3hof PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hof ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[https://omim.org/entry/604302 604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
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== Function ==
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[https://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ho/3hof_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hof ConSurf].
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<div style="clear:both"></div>
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===Structure of macrophage migration inhibitory factor (MIF) with caffeic acid at 1.9A resolution===
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==See Also==
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*[[Macrophage inhibitory factor 3D structures|Macrophage inhibitory factor 3D structures]]
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== References ==
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==Disease==
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<references/>
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Known disease associated with this structure: Persistent Mullerian duct syndrome, type I OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600957 600957]], Rheumatoid arthritis, systemic juvenile, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=153620 153620]]
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__TOC__
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</StructureSection>
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==About this Structure==
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3HOF is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HOF OCA].
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Phenylpyruvate tautomerase]]
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[[Category: Large Structures]]
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[[Category: Barker, J.]]
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[[Category: Barker J]]
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[[Category: Cheng, R K.Y.]]
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[[Category: Cheng RKY]]
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[[Category: Crawley, L.]]
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[[Category: Crawley L]]
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[[Category: Felicetti, B.]]
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[[Category: Felicetti B]]
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[[Category: Wood, M.]]
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[[Category: Wood M]]
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[[Category: Cytokine]]
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[[Category: Homotrimer]]
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[[Category: Inflammatory response]]
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[[Category: Isomerase]]
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[[Category: Phosphoprotein]]
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[[Category: Tautomerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 17 11:36:30 2009''
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Current revision

Structure of macrophage migration inhibitory factor (MIF) with caffeic acid at 1.9A resolution

PDB ID 3hof

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