3goe

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{{Seed}}
 
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[[Image:3goe.png|left|200px]]
 
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==Molecular Mimicry of SUMO promotes DNA repair==
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The line below this paragraph, containing "STRUCTURE_3goe", creates the "Structure Box" on the page.
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<StructureSection load='3goe' size='340' side='right'caption='[[3goe]], [[Resolution|resolution]] 0.97&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3goe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GOE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GOE FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.97&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_3goe| PDB=3goe | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3goe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3goe OCA], [https://pdbe.org/3goe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3goe RCSB], [https://www.ebi.ac.uk/pdbsum/3goe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3goe ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RAD60_SCHPO RAD60_SCHPO] Required for repair of DNA double strand breaks which occur during replication, or induced by UV or gamma radiation, via recombination between sister chromatids. This has a subsequent role in the maintenance of chromosome structure. May work in conjunction with the Smc5-Smc6 complex.<ref>PMID:11971984</ref> <ref>PMID:12897162</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/go/3goe_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3goe ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Rad60 family members contain functionally enigmatic, integral SUMO-like domains (SLDs). We show here that despite their divergence from SUMO, each Rad60 SLD interacts with a subset of SUMO pathway enzymes: SLD2 specifically binds the SUMO E2 conjugating enzyme (Ubc9), whereas SLD1 binds the SUMO E1 (Fub2, also called Uba2) activating and E3 (Pli1, also called Siz1 and Siz2) specificity enzymes. The molecular basis of this selectivity is revealed by our 0.97-A resolution crystal structure of Rad60 SLD2, which shows that apart from the conserved non-substrate SUMO:Ubc9 interface, the surface features of SLD2 are distinct from those of SUMO. Abrogation of the SLD2:Ubc9 FEG motif-dependent interaction results in hypersensitivity to genotoxic stress and an increase in spontaneous recombination associated with aberrant replication forks. Our results provide a mechanistic basis for the near-synonymous roles of Rad60 and SUMO in survival of genotoxic stress and suggest unprecedented DNA-damage-response functions for SLDs in regulating sumoylation.
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===Molecular Mimicry of SUMO promotes DNA repair===
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Molecular mimicry of SUMO promotes DNA repair.,Prudden J, Perry JJ, Arvai AS, Tainer JA, Boddy MN Nat Struct Mol Biol. 2009 May;16(5):509-16. Epub 2009 Apr 12. PMID:19363481<ref>PMID:19363481</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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3GOE is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GOE OCA].
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<div class="pdbe-citations 3goe" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Schizosaccharomyces pombe]]
[[Category: Schizosaccharomyces pombe]]
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[[Category: Perry, J J.P.]]
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[[Category: Perry JJP]]
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[[Category: Dna damage]]
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[[Category: Dna recombination]]
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[[Category: Dna repair]]
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[[Category: Genome stability]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Recombination]]
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[[Category: Replication]]
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[[Category: Sumo]]
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[[Category: Sumo-like domain]]
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[[Category: Sumoylation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 17 20:16:01 2009''
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Current revision

Molecular Mimicry of SUMO promotes DNA repair

PDB ID 3goe

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