1exl

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(New page: 200px<br /><applet load="1exl" size="450" color="white" frame="true" align="right" spinBox="true" caption="1exl" /> '''STRUCTURE OF AN 11-MER DNA DUPLEX CONTAINING...)
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[[Image:1exl.gif|left|200px]]<br /><applet load="1exl" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1exl" />
 
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'''STRUCTURE OF AN 11-MER DNA DUPLEX CONTAINING THE CARBOCYCLIC NUCLEOTIDE ANALOG: 2'-DEOXYARISTEROMYCIN'''<br />
 
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==Overview==
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==STRUCTURE OF AN 11-MER DNA DUPLEX CONTAINING THE CARBOCYCLIC NUCLEOTIDE ANALOG: 2'-DEOXYARISTEROMYCIN==
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2'-deoxyaristeromycin (dAr) is a nucleoside analogue that is resistant to, the action of DNA glycosylases. High-resolution NMR spectroscopy and, molecular dynamics simulations were used to determine the, three-dimensional structure of an 11-mer DNA containing a single dAr.T, base pair at its center. Analysis of the spectra revealed the existence of, a right-handed duplex in solution, stabilized by Watson-Crick hydrogen, bonding and base-stacking interactions. The carbocyclic sugar adopted a, C1'-exo conformation and sugars of the 3'-flanking base pair had puckers, in the O4'-endo range. The dAr.T base pair was mildly propeller twisted, and the dAr analogue showed a positive roll with the 3'-flanking base. Our, findings indicate that the observed resistance of dAr-containing, oligodeoxynucleotides to the catalytic action of DNA glycosylases relates, to its electronic properties rather than structure, and validate the use, of dAr and related carbocyclic nucleoside analogues for biological and, structure/function relationship studies.
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<StructureSection load='1exl' size='340' side='right'caption='[[1exl]]' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1exl]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EXL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EXL FirstGlance]. <br>
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1EXL is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1EXL OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2AR:2-DEOXYARISTEROMYCIN-5-PHOSPHATE'>2AR</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1exl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1exl OCA], [https://pdbe.org/1exl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1exl RCSB], [https://www.ebi.ac.uk/pdbsum/1exl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1exl ProSAT]</span></td></tr>
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Structure of an 11-mer DNA duplex containing the carbocyclic nucleotide analog: 2'-deoxyaristeromycin., Smirnov S, Johnson F, Marumoto R, de los Santos C, J Biomol Struct Dyn. 2000 Jun;17(6):981-91. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10949165 10949165]
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</table>
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[[Category: Protein complex]]
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__TOC__
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[[Category: Johnson, F.]]
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</StructureSection>
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[[Category: Marumoto, R.]]
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[[Category: Large Structures]]
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[[Category: Santos, C.de.los.]]
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[[Category: Johnson F]]
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[[Category: Smirnov, S.]]
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[[Category: Marumoto R]]
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[[Category: 2'-deoxyaristeromycin]]
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[[Category: Smirnov S]]
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[[Category: dna]]
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[[Category: De los Santos C]]
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[[Category: modified nucleotides]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 22:59:29 2007''
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Current revision

STRUCTURE OF AN 11-MER DNA DUPLEX CONTAINING THE CARBOCYCLIC NUCLEOTIDE ANALOG: 2'-DEOXYARISTEROMYCIN

PDB ID 1exl

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