3dr1

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{{Seed}}
 
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[[Image:3dr1.png|left|200px]]
 
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==Side-chain fluorine atoms of non-steroidal vitamin D3 analogs stabilize helix 12 of vitamin D receptor==
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The line below this paragraph, containing "STRUCTURE_3dr1", creates the "Structure Box" on the page.
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<StructureSection load='3dr1' size='340' side='right'caption='[[3dr1]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3dr1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DR1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DR1 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C5D:(1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-TRIMETHYL-3-[6,6,6-TRIFLUORO-5-HYDROXY-5-(TRIFLUOROMETHYL)HEX-3-YN-1-YL]CYCLOPENTYL}PROP-2-EN-1-YLIDENE]CYCLOHEXANE-1,3-DIOL'>C5D</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_3dr1| PDB=3dr1 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dr1 OCA], [https://pdbe.org/3dr1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dr1 RCSB], [https://www.ebi.ac.uk/pdbsum/3dr1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dr1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VDRA_DANRE VDRA_DANRE] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Plays a central role in calcium homeostasis.<ref>PMID:17218092</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dr/3dr1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dr1 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Side chain fluorination is often used to make analogs of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] resistant to degradation by 24-hydroxylase. The fluorinated nonsteroidal analogs CD578, WU515, and WY1113 have an increased prodifferentiating action on SW480-ADH colon cancer cells, which correlated with stronger induction of vitamin D receptor (VDR)-coactivator interactions and stronger repression of beta-catenin/TCF activity. Cocrystallization of analog CD578 with the zebrafish (z)VDR and an SRC-1 coactivator peptide showed that the fluorine atoms of CD578 make additional contacts with Val444 and Phe448 of activation helix 12 (H12) of the zVDR and with Leu440 of the H11-H12 loop. Consequently, the SRC-1 peptide makes more contacts with the VDR-CD578 complex than with the VDR-1,25(OH)2D3 complex. These data show that fluorination not only affects degradation of an analog but can also have direct effects on H12 stabilization.
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===Side-chain fluorine atoms of non-steroidal vitamin D3 analogs stabilize helix 12 of vitamin D receptor===
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Superagonistic fluorinated vitamin D3 analogs stabilize helix 12 of the vitamin D receptor.,Eelen G, Valle N, Sato Y, Rochel N, Verlinden L, De Clercq P, Moras D, Bouillon R, Munoz A, Verstuyf A Chem Biol. 2008 Oct 20;15(10):1029-34. PMID:18940664<ref>PMID:18940664</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 3dr1" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18940664 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18940664}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3DR1 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DR1 OCA].
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==Reference==
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<ref group="xtra">PMID:18940664</ref><references group="xtra"/>
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[[Category: Danio rerio]]
[[Category: Danio rerio]]
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[[Category: Histone acetyltransferase]]
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[[Category: Homo sapiens]]
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[[Category: Moras, D.]]
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[[Category: Large Structures]]
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[[Category: Rochel, N.]]
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[[Category: Moras D]]
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[[Category: Sato, Y.]]
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[[Category: Rochel N]]
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[[Category: Activator]]
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[[Category: Sato Y]]
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[[Category: Acyltransferase]]
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[[Category: Alternative splicing]]
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[[Category: Chromosomal rearrangement]]
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[[Category: Dna-binding]]
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[[Category: Gene regulation]]
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[[Category: Gene regulation/transferase complex]]
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[[Category: Metal-binding]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Proto-oncogene]]
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[[Category: Receptor]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Transferase]]
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[[Category: Ubl conjugation]]
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[[Category: Zinc]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 25 08:28:01 2009''
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Current revision

Side-chain fluorine atoms of non-steroidal vitamin D3 analogs stabilize helix 12 of vitamin D receptor

PDB ID 3dr1

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