2kji

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{{Seed}}
 
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[[Image:2kji.png|left|200px]]
 
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==A divergent ins protein in c. elegans structurally resemble insulin and activates the human insulin receptor==
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The line below this paragraph, containing "STRUCTURE_2kji", creates the "Structure Box" on the page.
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<StructureSection load='2kji' size='340' side='right'caption='[[2kji]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2kji]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KJI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KJI FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kji OCA], [https://pdbe.org/2kji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kji RCSB], [https://www.ebi.ac.uk/pdbsum/2kji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kji ProSAT]</span></td></tr>
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{{STRUCTURE_2kji| PDB=2kji | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ILB5_CAEEL ILB5_CAEEL]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kj/2kji_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kji ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Caenorhabditis elegans contains a family of putative insulin-like genes proposed to regulate dauer arrest and senescence. These sequences often lack characteristic sequence features of human insulin essential for its folding, structure, and function. Here, we describe the structure and receptor-binding properties of INS-6, a single-chain polypeptide expressed in specific neurons. Despite multiple nonconservative changes in sequence, INS-6 recapitulates an insulin-like fold. Although lacking classical receptor-binding determinants, INS-6 binds to and activates the human insulin receptor. Its activity is greater than that of an analogous single-chain human insulin analog.
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===A divergent ins protein in c. elegans structurally resemble insulin and activates the human insulin receptor===
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A divergent INS protein in Caenorhabditis elegans structurally resembles human insulin and activates the human insulin receptor.,Hua QX, Nakagawa SH, Wilken J, Ramos RR, Jia W, Bass J, Weiss MA Genes Dev. 2003 Apr 1;17(7):826-31. doi: 10.1101/gad.1058003. Epub 2003 Mar 21. PMID:12654724<ref>PMID:12654724</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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2KJI is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KJI OCA].
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<div class="pdbe-citations 2kji" style="background-color:#fffaf0;"></div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:12670864</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Caenorhabditis elegans]]
[[Category: Caenorhabditis elegans]]
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[[Category: Bass, J.]]
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[[Category: Large Structures]]
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[[Category: Hua, Q X.]]
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[[Category: Bass J]]
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[[Category: Jia, W H.]]
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[[Category: Hua QX]]
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[[Category: Nakarawa, S H.]]
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[[Category: Jia WH]]
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[[Category: Ramos, R R.]]
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[[Category: Nakarawa SH]]
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[[Category: Weiss, M A.]]
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[[Category: Ramos RR]]
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[[Category: Wilken, R.]]
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[[Category: Weiss MA]]
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[[Category: C. elegan]]
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[[Category: Wilken R]]
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[[Category: Cleavage on pair of basic residue]]
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[[Category: Disulfide bond]]
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[[Category: Folding]]
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[[Category: Hormone]]
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[[Category: Ins-6]]
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[[Category: Insulin like peptide]]
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[[Category: Nmr]]
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[[Category: Secreted]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 25 08:28:40 2009''
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Current revision

A divergent ins protein in c. elegans structurally resemble insulin and activates the human insulin receptor

PDB ID 2kji

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OCA

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