2wci

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{{Seed}}
 
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[[Image:2wci.jpg|left|200px]]
 
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==Structure of E. coli monothiol glutaredoxin GRX4 homodimer==
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The line below this paragraph, containing "STRUCTURE_2wci", creates the "Structure Box" on the page.
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<StructureSection load='2wci' size='340' side='right'caption='[[2wci]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2wci]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WCI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WCI FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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{{STRUCTURE_2wci| PDB=2wci | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wci OCA], [https://pdbe.org/2wci PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wci RCSB], [https://www.ebi.ac.uk/pdbsum/2wci PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wci ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GLRX4_ECOLI GLRX4_ECOLI] Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters (Probable).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wc/2wci_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wci ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Glutaredoxins (GRX) are redox proteins which use glutathione as a cofactor and are divided into two classes, monothiol and dithiol. In each class, several GRX have been shown to form [Fe2S2] cluster coordinating homodimers. The dithiol GRX homodimer is proposed to serve as a sequestration form and its iron-sulfur cluster as an oxidative stress sensor. In contrast, the monothiol GRX homodimer has been suggested to act as a scaffold for [Fe2S2] cluster delivery. We present here the structure of a monothiol GRX homodimer (Escherichia coli GRX4) coordinating a [Fe2S2] cluster that reveals the structural basis of intact iron-sulfur cluster delivery.
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===STRUCTURE OF E. COLI MONOTHIOL GLUTAREDOXIN GRX4 HOMODIMER===
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Structural Basis for Delivery of the Intact [Fe2S2] Cluster by Monothiol Glutaredoxin.,Iwema T, Picciocchi A, Traore DA, Ferrer JL, Chauvat F, Jacquamet L Biochemistry. 2009 Jun 15. PMID:19505088<ref>PMID:19505088</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19505088}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2wci" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19505088 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19505088}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2WCI is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WCI OCA].
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==Reference==
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<ref group="xtra">PMID:19505088</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Chauvat, F.]]
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[[Category: Large Structures]]
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[[Category: Ferrer, J L.]]
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[[Category: Chauvat F]]
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[[Category: Iwema, T.]]
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[[Category: Ferrer J-L]]
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[[Category: Jacquamet, L.]]
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[[Category: Iwema T]]
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[[Category: Picchiocci, A.]]
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[[Category: Jacquamet L]]
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[[Category: Traore, D A.K.]]
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[[Category: Picchiocci A]]
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[[Category: Cytoplasm]]
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[[Category: Traore DAK]]
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[[Category: Electron transport]]
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[[Category: Fe2s2]]
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[[Category: Glutathione]]
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[[Category: Homodimer]]
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[[Category: Iron-sulfur cluster scaffolder]]
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[[Category: Redox-active center]]
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[[Category: Thioredoxin fold]]
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[[Category: Transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 25 09:06:27 2009''
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Current revision

Structure of E. coli monothiol glutaredoxin GRX4 homodimer

PDB ID 2wci

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OCA

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