This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2wci

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:11, 9 May 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2wci.jpg|left|200px]]
 
-
<!--
+
==Structure of E. coli monothiol glutaredoxin GRX4 homodimer==
-
The line below this paragraph, containing "STRUCTURE_2wci", creates the "Structure Box" on the page.
+
<StructureSection load='2wci' size='340' side='right'caption='[[2wci]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2wci]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WCI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WCI FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-
{{STRUCTURE_2wci| PDB=2wci | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wci OCA], [https://pdbe.org/2wci PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wci RCSB], [https://www.ebi.ac.uk/pdbsum/2wci PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wci ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/GLRX4_ECOLI GLRX4_ECOLI] Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters (Probable).
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wc/2wci_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wci ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Glutaredoxins (GRX) are redox proteins which use glutathione as a cofactor and are divided into two classes, monothiol and dithiol. In each class, several GRX have been shown to form [Fe2S2] cluster coordinating homodimers. The dithiol GRX homodimer is proposed to serve as a sequestration form and its iron-sulfur cluster as an oxidative stress sensor. In contrast, the monothiol GRX homodimer has been suggested to act as a scaffold for [Fe2S2] cluster delivery. We present here the structure of a monothiol GRX homodimer (Escherichia coli GRX4) coordinating a [Fe2S2] cluster that reveals the structural basis of intact iron-sulfur cluster delivery.
-
===STRUCTURE OF E. COLI MONOTHIOL GLUTAREDOXIN GRX4 HOMODIMER===
+
Structural Basis for Delivery of the Intact [Fe2S2] Cluster by Monothiol Glutaredoxin.,Iwema T, Picciocchi A, Traore DA, Ferrer JL, Chauvat F, Jacquamet L Biochemistry. 2009 Jun 15. PMID:19505088<ref>PMID:19505088</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_19505088}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 2wci" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 19505088 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_19505088}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
2WCI is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WCI OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:19505088</ref><references group="xtra"/>
+
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
-
[[Category: Chauvat, F.]]
+
[[Category: Large Structures]]
-
[[Category: Ferrer, J L.]]
+
[[Category: Chauvat F]]
-
[[Category: Iwema, T.]]
+
[[Category: Ferrer J-L]]
-
[[Category: Jacquamet, L.]]
+
[[Category: Iwema T]]
-
[[Category: Picchiocci, A.]]
+
[[Category: Jacquamet L]]
-
[[Category: Traore, D A.K.]]
+
[[Category: Picchiocci A]]
-
[[Category: Cytoplasm]]
+
[[Category: Traore DAK]]
-
[[Category: Electron transport]]
+
-
[[Category: Fe2s2]]
+
-
[[Category: Glutathione]]
+
-
[[Category: Homodimer]]
+
-
[[Category: Iron-sulfur cluster scaffolder]]
+
-
[[Category: Redox-active center]]
+
-
[[Category: Thioredoxin fold]]
+
-
[[Category: Transport]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 25 09:06:27 2009''
+

Current revision

Structure of E. coli monothiol glutaredoxin GRX4 homodimer

PDB ID 2wci

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2wci"
Personal tools