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2fr7
From Proteopedia
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| - | {{Seed}} | ||
| - | [[Image:2fr7.png|left|200px]] | ||
| - | + | ==Crystal Structure of Cytochrome P450 CYP199A2== | |
| - | + | <StructureSection load='2fr7' size='340' side='right'caption='[[2fr7]], [[Resolution|resolution]] 2.01Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2fr7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodopseudomonas_palustris_CGA009 Rhodopseudomonas palustris CGA009]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FR7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FR7 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fr7 OCA], [https://pdbe.org/2fr7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fr7 RCSB], [https://www.ebi.ac.uk/pdbsum/2fr7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fr7 ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/CYPA2_RHOPA CYPA2_RHOPA] The oxidative demethylation of 4-methoxybenzoate requires the participation of the monooxygenase CYP199A2, the ferredoxin-like protein ThcC/RPA1872 and a ferredoxin reductase to mediate the transfer of electrons from NADH to CYP199A2. It is also active with 4-ethylbenzoate.<ref>PMID:16472768</ref> <ref>PMID:18762195</ref> | |
| - | + | == Evolutionary Conservation == | |
| - | < | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | + | Check<jmol> | |
| - | + | <jmolCheckbox> | |
| - | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fr/2fr7_consurf.spt"</scriptWhenChecked> | |
| - | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |
| - | + | <text>to colour the structure by Evolutionary Conservation</text> | |
| - | == | + | </jmolCheckbox> |
| - | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fr7 ConSurf]. | |
| - | + | <div style="clear:both"></div> | |
| - | == | + | == References == |
| - | < | + | <references/> |
| - | [[ | + | __TOC__ |
| - | [[ | + | </StructureSection> |
| - | [[ | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Rhodopseudomonas palustris CGA009]] |
| - | [[Category: | + | [[Category: Bell SG]] |
| - | [[Category: | + | [[Category: Rao Z]] |
| - | [[Category: | + | [[Category: Wong LL]] |
| - | + | [[Category: Xu F]] | |
| - | + | ||
Current revision
Crystal Structure of Cytochrome P450 CYP199A2
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