1rsb

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(New page: 200px<br /><applet load="1rsb" size="450" color="white" frame="true" align="right" spinBox="true" caption="1rsb, resolution 2.17&Aring;" /> '''X-ray study of the D...)
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[[Image:1rsb.gif|left|200px]]<br /><applet load="1rsb" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1rsb, resolution 2.17&Aring;" />
 
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'''X-ray study of the DNA oligomer d(ATATAT) in P65 space group'''<br />
 
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==Overview==
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==X-ray study of the DNA oligomer d(ATATAT) in P65 space group==
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We present and analyze the structure of the oligonucleotide d(ATATAT), found in two different forms by X-ray crystallography and in solution by, NMR. We find that in both crystal lattices the oligonucleotide forms an, antiparallel double helical duplex in which base pairing is of the, Hoogsteen type. The double helix is apparently very similar to the, standard B-form of DNA, with about 10 base pairs per turn. However, the, adenines in the duplex are flipped over; as a result, the physicochemical, features of both grooves of the helix are changed. In particular, the, minor groove is narrow and hydrophobic. On the other hand, d(ATATAT), displays a propensity to adopt the B conformation in solution. These, results confirm the polymorphism of AT-rich sequences in DNA. Furthermore, we show that extrahelical adenines and thymines can be minor groove, binders in Hoogsteen DNA.
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<StructureSection load='1rsb' size='340' side='right'caption='[[1rsb]], [[Resolution|resolution]] 2.17&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1rsb]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RSB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RSB FirstGlance]. <br>
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1RSB is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1RSB OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.17&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rsb OCA], [https://pdbe.org/1rsb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rsb RCSB], [https://www.ebi.ac.uk/pdbsum/1rsb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rsb ProSAT]</span></td></tr>
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==Reference==
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</table>
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X-ray and NMR studies of the DNA oligomer d(ATATAT): Hoogsteen base pairing in duplex DNA., Abrescia NG, Gonzalez C, Gouyette C, Subirana JA, Biochemistry. 2004 Apr 13;43(14):4092-100. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15065851 15065851]
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__TOC__
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[[Category: Protein complex]]
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</StructureSection>
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[[Category: Abrescia, N.G.]]
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[[Category: Large Structures]]
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[[Category: Gonzalez, C.]]
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[[Category: Abrescia NG]]
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[[Category: Gouyette, C.]]
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[[Category: Gonzalez C]]
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[[Category: Subirana, J.A.]]
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[[Category: Gouyette C]]
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[[Category: antiparallel hoogsteen dna]]
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[[Category: Subirana JA]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 23:11:16 2007''
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Current revision

X-ray study of the DNA oligomer d(ATATAT) in P65 space group

PDB ID 1rsb

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