1aqo

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(New page: 200px<br /><applet load="1aqo" size="450" color="white" frame="true" align="right" spinBox="true" caption="1aqo" /> '''IRON RESPONSIVE ELEMENT RNA HAIRPIN, NMR, 15...)
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[[Image:1aqo.gif|left|200px]]<br /><applet load="1aqo" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1aqo" />
 
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'''IRON RESPONSIVE ELEMENT RNA HAIRPIN, NMR, 15 STRUCTURES'''<br />
 
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==Overview==
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==IRON RESPONSIVE ELEMENT RNA HAIRPIN, NMR, 15 STRUCTURES==
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The iron responsive element (IRE) is a approximately 30 nucleotide RNA, hairpin that is located in the 5' untranslated region of all ferritin, mRNAs and in the 3' untranslated region of all transferrin receptor mRNAs., The IREs are bound by two related IRE-binding proteins (IRPs) which help, control intracellular levels of iron by regulating the expression of both, ferritin and transferrin receptor genes. Multi-dimensional NMR and, computational approaches were used to study the structure and dynamics of, the IRE RNA in solution. The NMR data are consistent with formation of, A-form helical stem regions, a one-base internal bulge and a Watson-Crick, C.G base-pair between the first and fifth nucleotides in the loop. A, superposition of refined structures indicates that the conserved C in the, internal bulge, and three residues in the six-nucleotide hairpin loop are, quite dynamic in this RNA. The structural roles of the stems, the loop and, the bulge in the function of the IRE RNA and in possible interactions with, the iron regulatory protein are discussed.
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<StructureSection load='1aqo' size='340' side='right'caption='[[1aqo]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1aqo]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AQO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AQO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aqo OCA], [https://pdbe.org/1aqo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aqo RCSB], [https://www.ebi.ac.uk/pdbsum/1aqo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aqo ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The iron responsive element (IRE) is a approximately 30 nucleotide RNA hairpin that is located in the 5' untranslated region of all ferritin mRNAs and in the 3' untranslated region of all transferrin receptor mRNAs. The IREs are bound by two related IRE-binding proteins (IRPs) which help control intracellular levels of iron by regulating the expression of both ferritin and transferrin receptor genes. Multi-dimensional NMR and computational approaches were used to study the structure and dynamics of the IRE RNA in solution. The NMR data are consistent with formation of A-form helical stem regions, a one-base internal bulge and a Watson-Crick C.G base-pair between the first and fifth nucleotides in the loop. A superposition of refined structures indicates that the conserved C in the internal bulge, and three residues in the six-nucleotide hairpin loop are quite dynamic in this RNA. The structural roles of the stems, the loop and the bulge in the function of the IRE RNA and in possible interactions with the iron regulatory protein are discussed.
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==About this Structure==
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Structure and dynamics of the iron responsive element RNA: implications for binding of the RNA by iron regulatory binding proteins.,Addess KJ, Basilion JP, Klausner RD, Rouault TA, Pardi A J Mol Biol. 1997 Nov 21;274(1):72-83. PMID:9398517<ref>PMID:9398517</ref>
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1AQO is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AQO OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Structure and dynamics of the iron responsive element RNA: implications for binding of the RNA by iron regulatory binding proteins., Addess KJ, Basilion JP, Klausner RD, Rouault TA, Pardi A, J Mol Biol. 1997 Nov 21;274(1):72-83. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9398517 9398517]
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</div>
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[[Category: Protein complex]]
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<div class="pdbe-citations 1aqo" style="background-color:#fffaf0;"></div>
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[[Category: Addess, K.J.]]
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== References ==
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[[Category: Pardi, A.]]
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<references/>
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[[Category: hairpin]]
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__TOC__
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[[Category: ribonucleic acid]]
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</StructureSection>
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[[Category: rna]]
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[[Category: Large Structures]]
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[[Category: translational regulation]]
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[[Category: Addess KJ]]
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[[Category: Pardi A]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 23:12:59 2007''
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IRON RESPONSIVE ELEMENT RNA HAIRPIN, NMR, 15 STRUCTURES

PDB ID 1aqo

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