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3fyx

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{{Seed}}
 
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[[Image:3fyx.jpg|left|200px]]
 
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==The Structure of OmpF porin with a synthetic dibenzo-18-crown-6 as modulator==
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The line below this paragraph, containing "STRUCTURE_3fyx", creates the "Structure Box" on the page.
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<StructureSection load='3fyx' size='340' side='right'caption='[[3fyx]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3fyx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FYX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FYX FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=451:N-(6,7,9,10,17,18,20,21-OCTAHYDRODIBENZO[B,K][1,4,7,10,13,16]HEXAOXACYCLOOCTADECIN-2-YL)ACETAMIDE'>451</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
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{{STRUCTURE_3fyx| PDB=3fyx | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fyx OCA], [https://pdbe.org/3fyx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fyx RCSB], [https://www.ebi.ac.uk/pdbsum/3fyx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fyx ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/OMPF_ECOLI OMPF_ECOLI] Forms pores that allow passive diffusion of small molecules across the outer membrane. It is also a receptor for the bacteriophage T2.<ref>PMID:19721064</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fy/3fyx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fyx ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The attachment of modulators to a trimeric porin ion channel was investigated (see picture of the trimer with a crown ether modulator (orange)). The interplay of modulator and protein is essential for the conformational heterogeneity of the hybrid channel. Single-site attachment in large pores is not sufficient to change the electrophysiological characteristics of the pores-such change requires additional noncovalent interactions or second-site attachments.
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===The Structure of OmpF porin with a synthetic dibenzo-18-crown-6 as modulator===
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On the function and structure of synthetically modified porins.,Reitz S, Cebi M, Reiss P, Studnik G, Linne U, Koert U, Essen LO Angew Chem Int Ed Engl. 2009;48(26):4853-7. PMID:19322865<ref>PMID:19322865</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3fyx" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19322865}}, adds the Publication Abstract to the page
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*[[Porin 3D structures|Porin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19322865 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19322865}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Escherichia coli K-12]]
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3FYX is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k12 Escherichia coli k12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FYX OCA].
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[[Category: Large Structures]]
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[[Category: Cebi M]]
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==Reference==
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[[Category: Essen LO]]
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<ref group="xtra">PMID:19322865</ref><references group="xtra"/>
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[[Category: Koert U]]
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[[Category: Escherichia coli k12]]
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[[Category: Reitz S]]
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[[Category: Cebi, M.]]
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[[Category: Essen, L O.]]
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[[Category: Koert, U.]]
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[[Category: Reitz, S.]]
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[[Category: Beta-barrel]]
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[[Category: Cell membrane]]
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[[Category: Cell outer membrane]]
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[[Category: Crown ether]]
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[[Category: Ion transport]]
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[[Category: Ion-channel engineering]]
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[[Category: Membrane]]
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[[Category: Phage recognition]]
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[[Category: Porin]]
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[[Category: Porin structure]]
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[[Category: Synthetic ion-current modulator]]
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[[Category: Transmembrane]]
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[[Category: Transport]]
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[[Category: Transport protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 1 09:14:49 2009''
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Current revision

The Structure of OmpF porin with a synthetic dibenzo-18-crown-6 as modulator

PDB ID 3fyx

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