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3ft8

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{{Seed}}
 
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[[Image:3ft8.jpg|left|200px]]
 
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<!--
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==Structure of HSP90 bound with a noval fragment.==
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The line below this paragraph, containing "STRUCTURE_3ft8", creates the "Structure Box" on the page.
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<StructureSection load='3ft8' size='340' side='right'caption='[[3ft8]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ft8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FT8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FT8 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MOJ:(5E,7S)-2-AMINO-7-(4-FLUORO-2-PYRIDIN-3-YLPHENYL)-4-METHYL-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE+OXIME'>MOJ</scene></td></tr>
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{{STRUCTURE_3ft8| PDB=3ft8 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ft8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ft8 OCA], [https://pdbe.org/3ft8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ft8 RCSB], [https://www.ebi.ac.uk/pdbsum/3ft8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ft8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ft/3ft8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ft8 ConSurf].
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<div style="clear:both"></div>
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===Structure of HSP90 bound with a noval fragment.===
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==See Also==
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*[[Heat Shock Protein structures|Heat Shock Protein structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 19301319 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_19301319}}
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==About this Structure==
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3FT8 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FT8 OCA].
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==Reference==
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<ref group="xtra">PMID:19301319</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Barker, J B.]]
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[[Category: Large Structures]]
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[[Category: Cheng, R K.Y.]]
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[[Category: Barker JB]]
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[[Category: Felicetti, B.]]
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[[Category: Cheng RKY]]
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[[Category: Palan, S.]]
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[[Category: Felicetti B]]
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[[Category: Alternative splicing]]
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[[Category: Palan S]]
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[[Category: Atp-binding]]
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[[Category: Chaperone]]
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[[Category: Cytoplasm]]
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[[Category: Hsp90 n-terminal nucleotide binding domain]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphoprotein]]
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[[Category: Stress response]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 1 09:18:07 2009''
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Current revision

Structure of HSP90 bound with a noval fragment.

PDB ID 3ft8

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