2zx1

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{{Seed}}
 
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[[Image:2zx1.jpg|left|200px]]
 
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==Rhamnose-binding lectin CSL3==
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The line below this paragraph, containing "STRUCTURE_2zx1", creates the "Structure Box" on the page.
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<StructureSection load='2zx1' size='340' side='right'caption='[[2zx1]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2zx1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Oncorhynchus_keta Oncorhynchus keta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZX1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZX1 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_2zx1| PDB=2zx1 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zx1 OCA], [https://pdbe.org/2zx1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zx1 RCSB], [https://www.ebi.ac.uk/pdbsum/2zx1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zx1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CSL3_ONCKE CSL3_ONCKE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zx/2zx1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zx1 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of the L-rhamnose-binding lectin CSL3 was determined to 1.8 A resolution. This protein is a component of the germline-encoded pattern recognition proteins in innate immunity. CSL3 is a homodimer of two 20 kDa subunits with a dumbbell-like shape overall, in which the N- and C-terminal domains of different subunits form lobe structures connected with flexible linker peptides. The complex structures of the protein with specific carbohydrates demonstrated the importance of the most variable loop region among homologues for the specificity toward oligosaccharides. CSL3 and Shiga-like toxin both use Gb(3) as a cellular receptor to evoke apoptosis. They have very different overall architecture but share the separation distance between carbohydrate-binding sites. An inspection of the structure database suggested that the pseudo-tetrameric structure of CSL3 was unique among the known lectins. This architecture implies this protein might provide a unique tool for further investigations into the relationships between architecture and function of pattern recognition proteins.
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===Rhamnose-binding lectin CSL3===
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Structure of rhamnose-binding lectin CSL3: unique pseudo-tetrameric architecture of a pattern recognition protein.,Shirai T, Watanabe Y, Lee MS, Ogawa T, Muramoto K J Mol Biol. 2009 Aug 14;391(2):390-403. Epub 2009 Jun 12. PMID:19524596<ref>PMID:19524596</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19524596}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2zx1" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19524596 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19524596}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2ZX1 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Oncorhynchus_keta Oncorhynchus keta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZX1 OCA].
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==Reference==
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<ref group="xtra">PMID:19524596</ref><references group="xtra"/>
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[[Category: Oncorhynchus keta]]
[[Category: Oncorhynchus keta]]
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[[Category: Lee, M.]]
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[[Category: Lee M]]
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[[Category: Muramoto, K.]]
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[[Category: Muramoto K]]
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[[Category: Ogawa, T.]]
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[[Category: Ogawa T]]
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[[Category: Shirai, T.]]
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[[Category: Shirai T]]
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[[Category: Watababe, Y.]]
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[[Category: Watababe Y]]
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[[Category: Immune system]]
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[[Category: Innate immunity]]
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[[Category: Lectin]]
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[[Category: Rhamnose]]
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[[Category: Sugar binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 1 09:18:12 2009''
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Current revision

Rhamnose-binding lectin CSL3

PDB ID 2zx1

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