2wft

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{{Seed}}
 
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[[Image:2wft.jpg|left|200px]]
 
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==Crystal structure of the human HIP ectodomain==
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The line below this paragraph, containing "STRUCTURE_2wft", creates the "Structure Box" on the page.
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<StructureSection load='2wft' size='340' side='right'caption='[[2wft]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2wft]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WFT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WFT FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wfx|2wfx]], [[2wg4|2wg4]], [[2wg3|2wg3]], [[2wfq|2wfq]], [[2wfr|2wfr]]</div></td></tr>
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{{STRUCTURE_2wft| PDB=2wft | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wft OCA], [https://pdbe.org/2wft PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wft RCSB], [https://www.ebi.ac.uk/pdbsum/2wft PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wft ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/HHIP_HUMAN HHIP_HUMAN]] Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family.<ref>PMID:11472839</ref> <ref>PMID:19561609</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wf/2wft_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wft ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Hedgehog (Hh) morphogens have fundamental roles in development, whereas dysregulation of Hh signaling leads to disease. Multiple cell-surface receptors are responsible for transducing and/or regulating Hh signals. Among these, the Hedgehog-interacting protein (Hhip) is a highly conserved, vertebrate-specific inhibitor of Hh signaling. We have solved a series of crystal structures for the human HHIP ectodomain and Desert hedgehog (DHH) in isolation, as well as HHIP in complex with DHH (HHIP-DHH) and Sonic hedgehog (Shh) (HHIP-Shh), with and without Ca2+. The interaction determinants, confirmed by biophysical studies and mutagenesis, reveal previously uncharacterized and distinct functions for the Hh Zn2+ and Ca2+ binding sites--functions that may be common to all vertebrate Hh proteins. Zn2+ makes a key contribution to the Hh-HHIP interface, whereas Ca2+ is likely to prevent electrostatic repulsion between the two proteins, suggesting an important modulatory role. This interplay of several metal binding sites suggests a tuneable mechanism for regulation of Hh signaling.
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===CRYSTAL STRUCTURE OF THE HUMAN HIP ECTODOMAIN===
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Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP.,Bishop B, Aricescu AR, Harlos K, O'Callaghan CA, Jones EY, Siebold C Nat Struct Mol Biol. 2009 Jul;16(7):698-703. Epub 2009 Jun 28. PMID:19561611<ref>PMID:19561611</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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2WFT is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WFT OCA].
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<div class="pdbe-citations 2wft" style="background-color:#fffaf0;"></div>
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[[Category: Homo sapiens]]
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== References ==
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[[Category: Aricescu, A R.]]
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<references/>
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[[Category: Bishop, B.]]
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__TOC__
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[[Category: Callaghan, C A.O.]]
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</StructureSection>
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[[Category: Harlos, K.]]
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[[Category: Human]]
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[[Category: Jones, E Y.]]
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[[Category: Large Structures]]
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[[Category: Siebold, C.]]
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[[Category: Aricescu, A R]]
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[[Category: Bishop, B]]
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[[Category: Callaghan, C A.O]]
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[[Category: Harlos, K]]
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[[Category: Jones, E Y]]
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[[Category: Siebold, C]]
[[Category: Alternative splicing]]
[[Category: Alternative splicing]]
[[Category: Cell membrane]]
[[Category: Cell membrane]]
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[[Category: Signal transduction]]
[[Category: Signal transduction]]
[[Category: Signaling protein]]
[[Category: Signaling protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 1 09:33:26 2009''
 

Current revision

Crystal structure of the human HIP ectodomain

PDB ID 2wft

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