1f84

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(New page: 200px<br /><applet load="1f84" size="450" color="white" frame="true" align="right" spinBox="true" caption="1f84" /> '''SOLUTION STRUCTURE OF HCV IRES RNA DOMAIN II...)
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[[Image:1f84.gif|left|200px]]<br /><applet load="1f84" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1f84" />
 
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'''SOLUTION STRUCTURE OF HCV IRES RNA DOMAIN IIID'''<br />
 
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==Overview==
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==SOLUTION STRUCTURE OF HCV IRES RNA DOMAIN IIID==
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Translation of the hepatitis C virus (HCV) polyprotein is initiated at an, internal ribosome entry site (IRES) element in the 5' untranslated region, of HCV RNA. The HCV IRES element interacts directly with the 40S subunit, and biochemical experiments have implicated RNA elements near the AUG, start codon as required for IRES-40S subunit complex formation. The data, we present here show that two RNA stem loops, domains IIId and IIIe, are, involved in IRES-40S subunit interaction. The structures of the two RNA, domains were solved by NMR spectroscopy and reveal structural features, that may explain their role in IRES function.
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<StructureSection load='1f84' size='340' side='right'caption='[[1f84]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1f84]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F84 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F84 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f84 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f84 OCA], [https://pdbe.org/1f84 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f84 RCSB], [https://www.ebi.ac.uk/pdbsum/1f84 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f84 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Translation of the hepatitis C virus (HCV) polyprotein is initiated at an internal ribosome entry site (IRES) element in the 5' untranslated region of HCV RNA. The HCV IRES element interacts directly with the 40S subunit, and biochemical experiments have implicated RNA elements near the AUG start codon as required for IRES-40S subunit complex formation. The data we present here show that two RNA stem loops, domains IIId and IIIe, are involved in IRES-40S subunit interaction. The structures of the two RNA domains were solved by NMR spectroscopy and reveal structural features that may explain their role in IRES function.
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==About this Structure==
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Structures of two RNA domains essential for hepatitis C virus internal ribosome entry site function.,Lukavsky PJ, Otto GA, Lancaster AM, Sarnow P, Puglisi JD Nat Struct Biol. 2000 Dec;7(12):1105-10. PMID:11101890<ref>PMID:11101890</ref>
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1F84 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1F84 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Structures of two RNA domains essential for hepatitis C virus internal ribosome entry site function., Lukavsky PJ, Otto GA, Lancaster AM, Sarnow P, Puglisi JD, Nat Struct Biol. 2000 Dec;7(12):1105-10. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11101890 11101890]
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</div>
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[[Category: Protein complex]]
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<div class="pdbe-citations 1f84" style="background-color:#fffaf0;"></div>
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[[Category: Lancaster, A.M.]]
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== References ==
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[[Category: Lukavsky, P.J.]]
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<references/>
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[[Category: Otto, G.A.]]
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__TOC__
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[[Category: Puglisi, J.D.]]
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</StructureSection>
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[[Category: Sarnow, P.]]
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[[Category: Large Structures]]
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[[Category: hairpin loop]]
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[[Category: Lancaster AM]]
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[[Category: hepatitis c virus internal ribosome entry site]]
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[[Category: Lukavsky PJ]]
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[[Category: loop e motif]]
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[[Category: Otto GA]]
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[[Category: ribonucleic acid]]
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[[Category: Puglisi JD]]
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[[Category: rna structure]]
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[[Category: Sarnow P]]
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[[Category: sarcin/ricin loop]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 23:28:04 2007''
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Current revision

SOLUTION STRUCTURE OF HCV IRES RNA DOMAIN IIID

PDB ID 1f84

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