3gbe

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{{Seed}}
 
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[[Image:3gbe.png|left|200px]]
 
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==Crystal structure of the isomaltulose synthase SmuA from Protaminobacter rubrum in complex with the inhibitor deoxynojirimycin==
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The line below this paragraph, containing "STRUCTURE_3gbe", creates the "Structure Box" on the page.
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<StructureSection load='3gbe' size='340' side='right'caption='[[3gbe]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3gbe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Serratia_plymuthica Serratia plymuthica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GBE FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=NOJ:1-DEOXYNOJIRIMYCIN'>NOJ</scene></td></tr>
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{{STRUCTURE_3gbe| PDB=3gbe | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gbe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbe OCA], [https://pdbe.org/3gbe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gbe RCSB], [https://www.ebi.ac.uk/pdbsum/3gbe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gbe ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/D0VX20_SERPL D0VX20_SERPL]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gb/3gbe_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gbe ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The healthy sweetener isomaltulose is industrially produced from the conversion of sucrose by the sucrose isomerase SmuA from Protaminobacter rubrum. Crystal structures of SmuA in native and deoxynojirimycin complexed forms completed with modeling studies unravel the characteristics of the isomaltulose synthases catalytic pocket and their substrate binding mode. Comparison with the trehalulose synthase MutB highlights the role of Arg(298) and Arg(306) active site residues and surface charges in controlling product specificity of sucrose isomerases (isomaltulose versus trehalulose). The results provide a rationale for the specific design of optimized enzymes.
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===Crystal structure of the isomaltulose synthase SmuA from Protaminobacter rubrum in complex with the inhibitor deoxynojirimycin===
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Structural determinants of product specificity of sucrose isomerases.,Ravaud S, Robert X, Watzlawick H, Haser R, Mattes R, Aghajari N FEBS Lett. 2009 Jun 18;583(12):1964-8. Epub 2009 May 8. PMID:19427862<ref>PMID:19427862</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3gbe" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19427862}}, adds the Publication Abstract to the page
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*[[Trehalulose synthase|Trehalulose synthase]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19427862 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19427862}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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3GBE is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Protaminobacter_rubrum Protaminobacter rubrum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBE OCA].
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[[Category: Serratia plymuthica]]
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[[Category: Aghajari N]]
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==Reference==
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[[Category: Haser R]]
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<ref group="xtra">PMID:19427862</ref><references group="xtra"/>
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[[Category: Ravaud S]]
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[[Category: Isomaltulose synthase]]
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[[Category: Robert X]]
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[[Category: Protaminobacter rubrum]]
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[[Category: Aghajari, N.]]
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[[Category: Haser, R.]]
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[[Category: Ravaud, S.]]
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[[Category: Robert, X.]]
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[[Category: Deoxynojirimycin complex]]
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[[Category: Glycoside hydrolase]]
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[[Category: Protaminobacter rubrum]]
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[[Category: Sucrose isomerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 1 09:54:22 2009''
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Current revision

Crystal structure of the isomaltulose synthase SmuA from Protaminobacter rubrum in complex with the inhibitor deoxynojirimycin

PDB ID 3gbe

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OCA

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