1jes

[[Image:1jes.gif|left|200px]]<br /><applet load="1jes" size="450" color="white" frame="true" align="right" spinBox="true"

caption="1jes, resolution 1.5&Aring;" />

'''Crystal Structure of a Copper-Mediated Base Pair in DNA'''<br />

==Overview==

Stable and selective DNA base pairing by metal coordination was recently, demonstrated with nucleotides containing complementary, pyridine-2,6-dicarboxylate (Dipic) and pyridine (Py) bases (Meggers, E.;, Holland, P. L.; Tolman; W. B.; Romesberg, F. E.; Schultz, P. G. J. Am., Chem. Soc. 2000, 122, 10714-10715). To understand the structural, consequences of introducing this novel base pair into DNA we have solved, the crystal structure of a duplex containing the metallo-base pair. The, structure shows that the bases pair as designed, but in a Z-DNA, conformation. The structure also provides a structural explanation for the, B- to Z-DNA transition in this duplex. Further solution studies, demonstrate that the metallo-base pair is compatible with Z- or B-DNA, conformations, depending on the duplex sequence.

 

==About this Structure==

1JES is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with CU as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JES OCA].

 

==Reference==

Structure of a copper-mediated base pair in DNA., Atwell S, Meggers E, Spraggon G, Schultz PG, J Am Chem Soc. 2001 Dec 12;123(49):12364-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11734038 11734038]

[[Category: Protein complex]]

[[Category: Atwell, S.]]

[[Category: Meggers, E.]]

[[Category: Schultz, P.G.]]

[[Category: Spraggon, G.]]

[[Category: designed]]

[[Category: dna]]

[[Category: dodecamer]]

[[Category: duplex]]

[[Category: metal]]