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3h6r
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Clitocypin, a beta-trefoil cysteine protease inhibitor== | |
| - | + | <StructureSection load='3h6r' size='340' side='right'caption='[[3h6r]], [[Resolution|resolution]] 1.95Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3h6r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clitocybe_nebularis Clitocybe nebularis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H6R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H6R FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.948Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h6r OCA], [https://pdbe.org/3h6r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h6r RCSB], [https://www.ebi.ac.uk/pdbsum/3h6r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h6r ProSAT]</span></td></tr> | |
| - | + | </table> | |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CLIT2_CLINE CLIT2_CLINE] Binds and inhibits cysteine proteinases. Inhibits most strongly papain and cathepsin L, more weakly bromelain and cathepsin B while it is completely ineffective against cathepsin H. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h6/3h6r_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3h6r ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Clitocybe nebularis]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Brzin J]] | ||
| + | [[Category: Renko M]] | ||
| + | [[Category: Sabotic J]] | ||
| + | [[Category: Turk D]] | ||
Current revision
Clitocypin, a beta-trefoil cysteine protease inhibitor
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