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2keg

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{{Seed}}
 
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[[Image:2keg.jpg|left|200px]]
 
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==NMR structure of Plantaricin K in DPC-micelles==
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The line below this paragraph, containing "STRUCTURE_2keg", creates the "Structure Box" on the page.
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<StructureSection load='2keg' size='340' side='right'caption='[[2keg]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2keg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactiplantibacillus_plantarum Lactiplantibacillus plantarum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KEG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KEG FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2keg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2keg OCA], [https://pdbe.org/2keg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2keg RCSB], [https://www.ebi.ac.uk/pdbsum/2keg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2keg ProSAT]</span></td></tr>
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{{STRUCTURE_2keg| PDB=2keg | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/P71460_LACPN P71460_LACPN]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The three-dimensional structures of the two peptides, PlnJ and PlnK, that constitutes the two-peptide bacteriocin plantaricin JK have been solved in water/TFE and water/DPC-micellar solutions using nuclear magnetic resonance (NMR) spectroscopy. PlnJ, a 25 residue peptide, has an N-terminal amphiphilic alpha-helix between Trp-3 and Tyr-15. The 32 residues long PlnK forms a central amphiphilic alpha-helix between Gly-9 and Leu-24. Measurements of the effect on anti-microbial activity of single glycine replacements in PlnJ and PlnK show that Gly-13 and Gly-17 in both peptides are very sensitive, giving more than a 100-fold reduction in activity when large residues replace glycine. In variants where other glycine residues, Gly-20 in PlnJ and Gly-7, Gly-9, Gly-24 and Gly-25 in PlnK, were replaced, the activity was reduced less than 10-fold. It is proposed that the detrimental effect on activity when exchanging Gly-13 and Gly-17 in PlnJ and PlnK is a result of reduced ability of the two peptides to interact through the GxxxG-motifs constituting Gly-13 and Gly-17.
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===NMR structure of Plantaricin K in DPC-micelles===
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Three-dimensional structure of the two-peptide bacteriocin plantaricin JK.,Rogne P, Haugen C, Fimland G, Nissen-Meyer J, Kristiansen PE Peptides. 2009 Sep;30(9):1613-21. Epub 2009 Jun 16. PMID:19538999<ref>PMID:19538999</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19538999}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2keg" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19538999 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19538999}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Lactiplantibacillus plantarum]]
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2KEG is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KEG OCA].
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[[Category: Large Structures]]
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[[Category: Fimland G]]
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==Reference==
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[[Category: Haugen M]]
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<ref group="xtra">PMID:19538999</ref><references group="xtra"/>
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[[Category: Kristiansen P]]
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[[Category: Fimland, G.]]
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[[Category: Nissen-Meyer J]]
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[[Category: Haugen, M.]]
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[[Category: Rogne P]]
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[[Category: Kristiansen, P.]]
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[[Category: Nissen-Meyer, J.]]
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[[Category: Rogne, P.]]
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[[Category: Antimicrobial protein]]
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[[Category: Peptide]]
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[[Category: Protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 8 09:25:57 2009''
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Current revision

NMR structure of Plantaricin K in DPC-micelles

PDB ID 2keg

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