3gx0

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{{Seed}}
 
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[[Image:3gx0.jpg|left|200px]]
 
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==Crystal Structure of GSH-dependent Disulfide bond Oxidoreductase==
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The line below this paragraph, containing "STRUCTURE_3gx0", creates the "Structure Box" on the page.
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<StructureSection load='3gx0' size='340' side='right'caption='[[3gx0]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3gx0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GX0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GX0 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDS:OXIDIZED+GLUTATHIONE+DISULFIDE'>GDS</scene></td></tr>
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{{STRUCTURE_3gx0| PDB=3gx0 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gx0 OCA], [https://pdbe.org/3gx0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gx0 RCSB], [https://www.ebi.ac.uk/pdbsum/3gx0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gx0 ProSAT]</span></td></tr>
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</table>
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===Crystal Structure of GSH-dependent Disulfide bond Oxidoreductase===
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== Function ==
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[https://www.uniprot.org/uniprot/YFCG_ECOLI YFCG_ECOLI] Exhibits a very robust glutathione (GSH)-dependent disulfide-bond reductase activity toward the model substrate, 2-hydroxyethyl disulfide; the actual physiological substrates are not known. Has also a low GSH-dependent hydroperoxidase activity toward cumene hydroperoxide, but does not reduce H(2)O(2), tert-butyl hydroperoxide, benzyl peroxide, or lauroyl peroxide. Exhibits little or no GSH transferase activity with most typical electrophilic substrates, and has no detectable transferase activity using glutathionylspermidine (GspSH) as the nucleophilic substrate. Is involved in defense against oxidative stress, probably via its peroxidase activity.<ref>PMID:17018556</ref> <ref>PMID:19537707</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 19537707 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gx/3gx0_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_19537707}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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3GX0 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GX0 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gx0 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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<ref group="xtra">PMID:19537707</ref><references group="xtra"/>
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<references/>
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[[Category: Escherichia coli]]
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__TOC__
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[[Category: Armstrong, R N.]]
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</StructureSection>
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[[Category: Harp, J M.]]
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[[Category: Escherichia coli K-12]]
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[[Category: Ladner, J E.]]
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[[Category: Large Structures]]
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[[Category: Wadington, M C.]]
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[[Category: Armstrong RN]]
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[[Category: Disulfide bond oxidoreductase]]
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[[Category: Harp JM]]
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[[Category: Glutathione]]
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[[Category: Ladner JE]]
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[[Category: Glutathione disulfide]]
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[[Category: Wadington MC]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 8 09:30:57 2009''
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Current revision

Crystal Structure of GSH-dependent Disulfide bond Oxidoreductase

PDB ID 3gx0

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